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CCN2 enhances osteoclastogenesis in addition to promoting actions toward chondrocytes, osteoblasts, and vascular endothelial cells. In other words, CCN2 promotes endochondral ossification by acting on all four types of cells that are involved in endochondral ossification, thus providing the so-called “Ecogenin” (Endochondral ossification genetic factor) action of CCN2. Modified from Takigawa et al. (2003)
