Fig 1.

Proportion of human papillomavirus type 16 (HPV16) E6 seropositive patients with oropharyngeal (OP) cancer and corresponding odds ratios by lead time from blood draw to cancer diagnosis. Blue bars indicate the proportion of patients with OP cancer who were HPV16 E6 seropositive. Black lines indicate risk of OP cancer by HPV16 E6 serostatus using polytomous logistic regression after adjustment for age at enrollment, sex, country, and tobacco and alcohol use. Numbers at the bottom of the figure indicate how many patients with OP cancer in each time interval.