Table 2.
Characteristics of Patients With Documented Refusal of or Contraindication to Curative Surgery, Adjuvant Therapy, or Therapy for Advanced Disease
| Characteristic | Curative Surgery |
Adjuvant Therapy |
Therapy for Advanced Disease |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of Eligible Patients | Refusal |
Contraindication |
No. of Eligible Patients | Refusal |
Contraindication |
No. of Eligible Patients | Refusal |
Contraindication |
|||||||
| No. | % | No. | % | No. | % | No. | % | No. | % | No. | % | ||||
| Overall | 1,447 | 90 | 6.2 | 397 | 27.4 | 273 | 33 | 12.1 | 60 | 22.0 | 2,329 | 140 | 6.0 | 434 | 18.6 |
| Age, years | |||||||||||||||
| < 55 | 93 | 2 | 2.2 | 13 | 14.0 | 24 | 2 | 8.3 | 5 | 20.8 | 181 | 4 | 2.2 | 31 | 17.1 |
| 55-64 | 467 | 18 | 3.9 | 105 | 22.5* | 112 | 10 | 8.9 | 23 | 20.5 | 948 | 35 | 3.7 | 126 | 13.3 |
| 65-79 | 702 | 42 | 6.0 | 197 | 28.1† | 124 | 17 | 13.7 | 28 | 22.6 | 956 | 73 | 7.6‡ | 191 | 20.0 |
| ≥ 80 | 185 | 28 | 15.1† | 82 | 44.3† | 13 | 4 | 30.8* | 4 | 30.8 | 244 | 28 | 11.5† | 86 | 35.3† |
| Sex | |||||||||||||||
| Male | 1,413 | 88 | 6.2 | 393 | 27.8 | 266 | 33 | 12.4 | 60 | 22.6 | 2,283 | 140 | 6.1 | 425 | 18.6 |
| Female | 34 | 2 | 5.9 | 4 | 11.8 | 7 | 0 | 0.0 | 0 | 0.0 | 46 | 0 | 0 | 9 | 19.6 |
| Race | |||||||||||||||
| White | 1,224 | 68 | 5.6 | 327 | 26.7 | 224 | 26 | 11.6 | 50 | 22.3 | 1,909 | 110 | 5.8 | 354 | 18.5 |
| Black | 196 | 21 | 10.7† | 64 | 32.7* | 37 | 4 | 10.8 | 8 | 21.6 | 378 | 26 | 6.9 | 73 | 19.1 |
| Other/unknown | 27 | 1 | 3.7 | 6 | 22.2 | 12 | 3 | 25.0 | 2 | 16.7 | 42 | 4 | 9.5 | 7 | 16.7 |
| Marital status | |||||||||||||||
| Married/living with partner | 696 | 35 | 5.0 | 182 | 26.2 | 134 | 14 | 10.5 | 35 | 26.1 | 1,105 | 62 | 5.6 | 191 | 17.3 |
| Other | 751 | 55 | 7.3 | 215 | 28.6 | 139 | 19 | 13.7 | 25 | 18.0 | 1,224 | 78 | 6.4 | 243 | 19.9 |
| Residence | |||||||||||||||
| Urban | 979 | 64 | 6.1 | 286 | 27.4 | 180 | 25 | 12.2 | 45 | 22.0 | 1,628 | 97 | 6.0 | 319 | 19.6 |
| Rural | 404 | 26 | 6.4 | 111 | 27.5 | 68 | 8 | 11.8 | 15 | 22.1 | 701 | 43 | 6.1 | 115 | 16.4 |
| NSCLC stage | |||||||||||||||
| I | 768 | 71 | 9.2† | 241 | 31.4† | — | — | — | — | — | — | — | — | — | — |
| II | 679 | 19 | 2.8 | 156 | 23.0 | 152 | 23 | 15.1 | 31 | 20.4 | — | — | — | — | — |
| III | — | — | — | — | — | 121 | 10 | 8.3 | 29 | 24.0 | 842 | 121 | 14.4 | 249 | 29.6 |
| IV | — | — | — | — | — | — | — | — | — | — | 1,053 | 15 | 1.4 | 162 | 15.4 |
| SCLC | |||||||||||||||
| Limited disease | — | — | — | — | — | — | — | — | — | — | 157 | 0 | 0 | 3 | 1.9 |
| Extensive disease | — | — | — | — | — | — | — | — | — | — | 239 | 4 | 1.7 | 19 | 8.0 |
| Unknown | — | — | — | — | — | — | — | — | — | — | 38 | 0 | 0 | 1 | 2.6 |
| Comorbidity level§ | |||||||||||||||
| None/mild/moderate | 1,061 | 64 | 6.0 | 251 | 23.7 | — | — | — | — | — | — | — | — | — | — |
| Severe | 386 | 26 | 6.7 | 146 | 37.8† | — | — | — | — | — | — | — | — | — | — |
| Pulmonary disease§ | |||||||||||||||
| None/mild/moderate | 1,162 | 72 | 6.2 | 282 | 24.3 | — | — | — | — | — | — | — | — | — | — |
| Severe | 285 | 18 | 6.3 | 115 | 40.4 | — | — | — | — | — | — | — | — | — | — |
| Surgery consultation§ | |||||||||||||||
| Yes | 1,192 | 56 | 4.7 | 199 | 16.7 | — | — | — | — | — | — | — | — | — | — |
| No | 255 | 34 | 13.3† | 198 | 77.7† | — | — | — | — | — | — | — | — | — | — |
| Medical oncology consultation | |||||||||||||||
| Yes | 1,010 | 68 | 6.7 | 345 | 34.2 | 245 | 30 | 12.2 | 49 | 20.0 | 789 | 93 | 11.8 | 237 | 30.0 |
| No | 437 | 22 | 5.0* | 52 | 11.9† | 28 | 3 | 10.7 | 11 | 39.3 | 1,540 | 47 | 3.1 | 197 | 12.8 |
Abbreviations: NSCLC, non–small-cell lung cancer; SCLC, small-cell lung cancer.
*
P < .05; multinomial univariate regression, with clustering by facility.
†
P ≤ .001; multinomial univariate regression, with clustering by facility.
‡
P < .01; multinomial univariate regression, with clustering by facility.
§
Data collected for stage I and II patients only.