Table 3.
Odds Ratio (OR) and 95% Confidence Interval (CI) for Placental Abruption in Relation to the Joint Effect of High Maternal Whole Blood Mitochondrial DNA Copy Numbers and Preeclampsia Status
| Whole Blood Mitochondrial DNA Copy Number & Preeclampsia | Whole Blood Mitochondrial DNA Copy Number(median (IQR)) | Placental Abruption Cases (N = 225) | Controls (N = 238) | Unadjusted OR (95% CI) | Adjusted OR* (95% CI) |
|---|---|---|---|---|---|
| Low & No | 209.8 (155.4-268.0) | 107 | 156 | 1.00 (reference) | 1.00 (reference) |
| High & No | 420.9 (366.0-528.9) | 48 | 54 | 1.30 (0.82-2.05) | 1.51 (0.92-2.48) |
| Low & Yes | 228.4 (146.8-262.6) | 45 | 22 | 2.98 (1.69-5.25) | 3.11 (1.70-5.67) |
| High & Yes | 431.2 (382.0-517.1) | 25 | 6 | 6.07 (2.41-15.31) | 6.66 (2.58-17.16) |
| P-value for interaction | 0.43 | 0.56 |
Note: 8 placental abruption cases had missing data for preeclampsia status and were thus excluded from this analysis. High mtDNA was defined (≥336.9, upper quartile); and low mtDNA was defined as (<336.9, lower three quartiles).
*
Adjusted for maternal pre-pregnancy body mass index, no prenatal care, and gestational age at delivery.