FIGURE 1.

Association of 5147 single nucleotide polymorphisms (SNPs) and three genes across the extended major histocompatibility complex (MHC) region in up to 227 African American type 1 diabetes and 471 controls. All analyses were adjusted for population ancestry using the first three principal components, and signal clouds were manually checked for SNPs discussed in the manuscript with positive associations. Note, the minor A allele at rs9273363, the most associated SNP, was in linkage disequilibrium with the highly susceptible HLA-DRB1*03:01-HLA-DQA1*05:01-HLA-DQB1*02:01 (r² = 0.43, D' = 1.00) and HLA-DRB1*04.HLA-DQA1*03:01-HLA-DQB1*03:02 haplotypes (r² = 0.23, D' = 1.00).