Table 1.
Allele frequencies and association results for HLA-DRB1 in 227 African American cases of Type 1 diabetes and 471 controls
| Allele frequency, n (%) | |||||
|---|---|---|---|---|---|
| HLA-DRB1 allele | Cases | Controls | Odds ratio [95% CI]‡ | Odds ratio [95% CI]‡ | PT1D |
| 03:01 | 85 (18.7) | 51 (5.4) | 3.17 [1.72–5.83] | 4.19 [2.56–6.88] | |
| 04* | 74 (16.3) | 58 (6.2) | 2.37 [1.27–4.42] | 3.13 [1.87–5.23] | |
| 09:01 | 26 (5.7) | 21 (2.2) | 2.35 [1.09–5.09] | 3.11 [1.55–6.27] | |
| 07:01 | 59 (13.0) | 81 (8.6) | 1.63 [0.89–2.99] | 2.15 [1.32–3.52] | |
| 01 | 26 (5.7) | 59 (6.3) | 1.00 (reference) | 1.32 [0.74–2.37] | |
| 08 | 29 (6.4) | 67 (7.1) | 0.86 [0.43–1.74] | 1.14 [0.66–1.99] | |
| 13 | 60 (13.2) | 163 (17.3) | 0.76 [0.42–1.36] | 1.00 (reference) | |
| 11 | 35 (7.7) | 135 (14.3) | 0.51 [0.28–0.96] | 0.68 [0.41–1.12] | |
| 15:03 | 20 (4.4) | 109 (11.6) | 0.39 [0.19–0.80] | 0.52 [0.29–0.94] | |
| 15:01 | 5 (1.1) | 23 (2.4) | 0.36 [0.11–1.11] | 0.47 [0.16–1.36] | |
| 12 | 7 (1.5) | 43 (4.6) | 0.36 [0.13–0.94] | 0.47 [0.19–1.14] | |
| 03:02 | 8 (1.8) | 66 (7.0) | 0.22 [0.09–0.55] | 0.29 [0.13–0.67] | |
| Rares† | 20 (4.4) | 66 (7.0) | 0.68 [0.32–1.42] | 0.90 [0.48–1.69] | |
| 16 | 5 (1.1) | 14 (1.5) | |||
| 10:01 | 10 (2.2) | 29 (3.1) | |||
| 14 | 3 (0.7) | 20 (2.1) | |||
| 03:03 | 1 (0.1) | ||||
| 15:02 | 2 (0.4) | 2 (0.2) | |||
| 7.79 × 10−26 | |||||
The gene was in Hardy–Weinberg equilibrium in controls, P = 0.38.
*
Frequencies of the four-digit subtypes are given in the Supporting Information (Table S3).
†
The rare alleles, 16,10:01, 14, 03:03, 15:02, were grouped together.
‡
Odds ratios were calculated with respect to a single reference allele using logistic regression (see Statistical methods).