Table 2.
Allele frequencies and association results for HLA-DQB1 in 225 African American cases of Type 1 diabetes and 461 controls
| Allele frequency, n (%) | |||||
|---|---|---|---|---|---|
| Allele | Cases | Controls | OR [95% CI]* | OR [95% CI]* | PT1D |
| 02:01 | 86 (19.1) | 48 (5.2) | 4.25 [2.47–7.32] | 1.94 [1.19–3.18] | |
| 03:02 | 63 (14.0) | 39 (4.2) | 3.46 [1.90–6.31] | 1.58 [0.93–2.71] | |
| 02:02 | 92 (20.4) | 115 (12.5) | 2.19 [1.30–3.67] | 1.00 (reference) | |
| 03 | 10 (2.2) | 28 (3.0) | 1.24 [0.51–3.04] | 0.57 [0.25–1.29] | |
| 06 | 33 (7.3) | 92 (10.0) | 1.00 (reference) | 0.46 [0.27–0.77] | |
| 05 | 64 (14.2) | 191 (20.7) | 0.96 [0.58–1.58] | 0.44 [0.29–0.67] | |
| 03:19 | 25 (5.6) | 82 (8.9) | 0.94 [0.50–1.74] | 0.43 [0.24–0.76] | |
| 03:01 | 25 (5.6) | 82 (8.9) | 0.82 [0.44–1.52] | 0.37 [0.21–0.66] | |
| 04:02 | 18 (4.0) | 66 (7.2) | 0.79 [0.40–1.56] | 0.36 [0.19–0.69] | |
| 06:02 | 34 (7.6) | 175 (19.0) | 0.54 [0.31–0.94] | 0.25 [0.15–0.40] | |
| 02:03 | 4 (0.4) | ||||
| 1.62 × 10−23 | |||||
The gene was in Hardy–Weinberg equilibrium in controls, P = 0.37.
*
Odds ratios were calculated with respect to a single reference allele using logistic regression (see Statistical methods).