Table 3.
Allele frequencies and association results for HLA-DQA1 in 225 African American cases of Type 1 diabetes and 461 controls
| Allele frequency, n (%) | |||||
|---|---|---|---|---|---|
| Allele | Cases | Controls | Odds ratio [95% CI]‡ | Odds ratio [95% CI]‡ | PT1D |
| 03:02 | 50 (11.1) | 18 (2.0) | 3.07 [1.65–5.71] | 5.09 [2.97–8.74] | |
| 05:01 | 88 (19.6) | 57 (6.2) | 2.67 [1.54–4.62] | 4.43 [2.81–6.97] | |
| 03:01 | 81 (18.0) | 84 (9.1) | 2.47 [1.44–4.25] | 4.09 [2.60–6.45] | |
| 02:01 | 38 (8.4) | 84 (9.1) | 1.00 (reference) | 1.66 [1.02–2.70] | |
| 01:01 | 43 (9.6) | 139 (15.1) | 0.72 [0.42–1.25] | 1.20 [0.76–1.90] | |
| Rares† | 15 (3.3) | 46 (5.0) | 0.69 [0.33–1.43] | 1.14 [0.59–2.21] | |
| 05:05 | 29 (6.4) | 112 (12.1) | 0.67 [0.37–1.22] | 1.11 [0.67–1.83] | |
| 04:01 | 31 (6.9) | 104 (11.3) | 0.67 [0.37–1.21] | 1.10 [0.67–1.82] | |
| 01:02 | 75 (16.7) | 278 (30.2) | 0.60 [0.37–0.98] | 1.00 (reference) | |
| 01:03 | 13 (2.9) | 41 (4.4) | |||
| 05:03 | 1 (0.1) | ||||
| 06:01 | 2 (0.4) | 4 (0.4) | |||
| 2.13 × 10−23 | |||||
The gene was in Hardy–Weinberg equilibrium in controls, P = 0.55.
†
Rare alleles comprise *01:03, *05:03, *06:01.
‡
Odds ratios were calculated with respect to a single reference allele using logistic regression (see Statistical methods).