The relationship between the fasting plasma triglyceride (mean baseline and 6 months) and the decrease in HbA1c in patients with Type 2 diabetes inadequately controlled on oral agents. Patients with low triglycerides (black bars, n = 22) had fasting plasma triglycerides ≤ 1.7 mmol/l. Patients with high triglycerides (grey bars, n = 18) had fasting plasma triglycerides > 1.7 mmol/l. The decreases in HbA1c from baseline in the patients with low triglycerides at 3, 6 and 12 months, respectively, were −15 ± 2.1, −16 ± 2.2 and −14 ± 3.0 mmol/mol (−1.4 ± 0.20,– −1.5 ± 0.20 and −1.3 ± 0.26%) and in the patients with high triglycerides −7 ± 1.7, −5 ± 1.6 and −5 ± 1.7 mmol/mol (−0.7 ± 0.16, −0.4 ± 0.18 and −0.4 ± 0.16%). P-values between the groups with low and high triglycerides at 3 and 12 months were 0.008 and at 6 months < 0.0001.