Fig. 5.
Action potential simulations using the TASK-1 Markov model show the influence of ITASK-1 on human atrial action potential. (A), Computational simulation of a normal action potential (black). Subtraction of ITASK-1 led to prolongation of APD and an increase in plateau voltage (blue). A 2fold increased ITASK-1 current shortened APD and decreased plateau voltage (red). (B), Net membrane currents with (black) and without (blue) ITASK-1. (C), L-type calcium current (ICaL) with (black) and without (blue) ITASK-1. (D-F), The effects of ITASK-1 subtraction on other currents. (D), Effects on IKur (black/blue). (E), Effects on IKr (black/grey) and IKs (green/blue). (F), Effects on the inward rectifier current (IK1) (black/blue).