Fig. 7.

SLC26A6 E298Q is a loss-of-function mutation. A. ¹⁴C-oxalate efflux traces into sequential baths of ND-96 and sodium cyclamate, from individual representative oocytes previously injected with water or with cRNA encoding wildtype SLC26A6 (hA6) or its mutant SLC26A6 E298Q. B. Mean ¹⁴C-oxalate efflux rate constants measured from (n) oocytes previously injected with water or with cRNA encoding SLC26A6 (hA6, 10 ng) or mutant E298Q (20 ng). **, p<0.01 vs, E298Q, 0.001 vs. water; *,p <0.01 vs. water. C. ¹⁴C-oxalate uptake into (n) oocytes previously injected with water or with cRNA encoding SLC26A6 (hA6, 10 ng) or its mutant E298Q (20 ng). **, p<0.001 vs. E298Q or water; *, p<0.05 vs. water. D. Mean ³⁶Cl⁻ influx into (n) oocytes previously injected with water or with cRNA encoding SLC26A6 (hA6, 10 ng) or its mutant E298Q (20 ng). *, p<0.05 vs. E298Q or water.