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. 2011 Nov;28(3):435–450. doi: 10.1159/000335106

Fig. 8.

Fig. 8

Protein kinase Cδ inhibits anion exchange mediated by hSLC26A2, hSLC26A3, hSLC26A6, or mSlc26a6, but not pendrin hSLC26A4. A. 36Cl− efflux traces from representative, individual oocytes previously injected with 1 ng hSLC26A4 cRNA without (filled circles) or with 50 ng hPKCδ-kinase-dead (hPKCδ-KD) cRNA (open circles). Oocytes were exposed sequentially to baths containing ND-96, Cl−-free cyclamate containing 100 nM PMA, ND-96 in the continued presence of PMA, then Cl−-free cyclamate. B. 14C-oxalate efflux traces from representative individual oocytes previously injected with 5 ng hSLC26A6 cRNA without (filled circles) or with 50 ng hPKCδ-KD cRNA (open circles), and exposed to the same sequence of bath solutions as in panel A. C. Mean ratios of efflux rate constants before (Keff1) and after (Keff2) PMA exposure comparing (n) oocytes expressing anion exchanger alone (gray bars) or together with hPKCδ-KD (white bars). *, p < 0.0005 vs absence of hPKCδ-KD.