Fig. 9.

Mutation of SLC26A2 Ser residues conserved among PMA-sensitive SLC26 gene products but absent from pendrin did not alter PMA inhibition of SLC26A2. A. Alignments of SLC26 anion exchangers tested in Fig. 7 showed one region (pictured) in which Ser and Thr residues (highlighted) were conserved in PMA-sensitive transporters but not in PMA-insensitive SLC26A4. hSLC26A2 S245 and S249 (highlighted in black) were selected for mutagenesis. B. Mean ³⁵SO₄²⁻ efflux rate constants from (n) oocytes studied as in panel B of Fig. 8. *, p < 0.00005, pre- vs. post-PMA.