Table 1.
Tests of candidate inhibitors of pendrin-mediated 36Cl− influx. % inhibition is presented in bold if statistically significant (p<0.05, one-way ANOVA), and in gray in parentheses if p>0.05.
| Candidate Inhibitor | n | Concentration (mM) | Mean 36C1− uptake (nmol h−1 ± SE) | P-Value | Inhibition(%) |
|---|---|---|---|---|---|
| Oocyte background (water-injected) | 29 | 0.17 ±0.05 | |||
| Without drug | 24 | 15.6 ±1.37 | |||
| DIDS, 20°C | 14 | 0.5 | 18.70 ±5.49 | ns | (0) |
| DIDS, 37°C | 8 | 0.5 | 14.72 ±10.16 | ns | (6) |
| DIDS, 20°C, chloride-free | 15 | 0.5 | 14.75 ±6.81 | ns | (5) |
| DIDS, 37°C, chloride-free | 8 | 0.5 | 19.65 ±14.53 | ns | (0) |
| Tenidap | 19 | 0.1 | 7.92 ±1.23 | <0.001 | 49 |
| Niflumic acid | 10 | 0.1 | 8.41 ±1.58 | 0.020 | 46 |
| NS 3623 | 8 | 0.1 | 10.1 ±2.37 | ns | (35) |
| Hydrochlorothiazide | 10 | 1 | 10.6 ±1.01 | ns | (32) |
| Flufenamic acid | 10 | 0.1 | 11.9 ±2.05 | ns | (24) |
| PMA | 10 | 0.01 | 12.1 ±2.18 | ns | (23) |
| a-Cyano-3-hydroxy-cinnamic acid | 10 | 1 | 13.5 ±1.61 | ns | (13) |
| 6-Ethoxy-2-Benzothiazolesulfenamide | 10 | 0.1 | 14.1 ±1.76 | ns | (10) |
| Wortmannin | 10 | 0.1 | 15.7 ±2.32 | ns | (0) |
| UK 5099 | 9 | 1 | 16.9 ±1.65 | ns | (0) |
| 4-Hydroxy-cinnamic acid | 6 | 1 | 19.6 ±3.35 | ns | (0) |
| Levamisole | 9 | 1 | 21.0 ±2.08 | ns | (0) |
| Trans-cinnamic acid | 9 | 1 | 22.1 ±1.55 | ns | (0) |