Table 2.
Cell and tissue phenotypes of mutations in mouse clock and clock-related genes
| Gene(s) | Mutant allele(s) | Cellular phenotype(s) | Tissue phenotype(s) | References |
|---|---|---|---|---|
| Clock | Clock−/− | — | SCN: WT; lung, liver: AR | (DeBruyne et al., 2007a; DeBruyne et al., 2007b) |
| Npas2 (Mop4) | Npas2−/− | — | SCN, lung, liver: WT | (DeBruyne et al., 2007b) |
| Bmal1 (Arntl, Mop3) | Bmal1−/− | Fibroblasts, SCN neurons: AR | SCN: variable/stochastic; pituitary, liver, lung, cornea: AR |
(Liu et al., 2008; Ko etal., 2010) |
| Cry1 | Cry1−/− | Fibroblasts, SCN neurons: AR | SCN: short; lung, liver, cornea: AR | (Liu et al., 2007b) |
| Cry2 | Cry2−/− | Fibroblasts, SCN neurons: long | SCN, lung, liver, cornea: long | (Liu et al., 2007b) |
| Cry1/Cry2 | Cry1−/−/Cry2−/− | Fibroblasts: AR | SCN, lung, liver, cornea: AR | (Yagita et al., 2001; Liu et al., 2007b) |
| Per1 | Per1ldc | Fibroblasts, SCN neurons: AR | SCN: WT; lung: AR | (Liu et al., 2007b) |
| Per2 | Per2ldc | Fibroblasts: AR | — | (Liu et al., 2007b) |
| Per3 | Per3−/− | Fibroblasts: short | SCN, lung: short | (Liu et al., 2007b) |
| Rev-erbα (Nr1d1) | Rev-erbα−/− | Fibroblasts: WT | — | (Liu et al., 2008) |
| Rorα (Rora) | Rorα−/− (staggerer) | Fibroblasts: WT | — | (Liu et al., 2008) |
| Rorγ (Rorc) | Rorγ−/− | Fibroblasts: WT | Lung, liver: WT | (Liu et al., 2008) |
| CK1δ (Csnk1d) | CK1δ−/− | Fibroblasts: long | *SCN, liver: long | (Etchegaray et al., 2009; Lee et al., 2009; Etchegaray et al., 2010) |
| CK1ε (Csnk1e) | CK1ε−/− | Fibroblasts: WT | *SCN, liver: WT | (Etchegaray et al., 2009; Etchegaray et al., 2010) |
| CK1εtau | Fibroblasts: short | SCN, pituitary, lung, kidney: short | (Meng et al., 2008) |
Gene symbols are as in Table 1. Abbreviations: AR, arrhythmic; WT, wild type;
*
neonatal tissue. Table modified from (Baggs et al., 2009).