Brain abscesses were induced in WT, TCR αβ KO, and TCR αβ KO mice that received an adoptive transfer of 106 purified CD3+CD4+ T cells (NKT-depleted) 24 h prior to S. aureus infection (n= 4-5/group). Animals were euthanized at the indicated time points post-infection, whereupon bacterial burdens were quantitated and normalized to tissue wet weight (g), and neutrophil and macrophage infiltrates determined by FACS. Significant differences between PBS-injected TCR αβ KO mice versus TCR αβ KO animals receiving adoptively transferred T cells are denoted by asterisks (*, p < 0.05). Results represent the mean ± SEM combined from three independent experiments.