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. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: J Immunol. 2011 Dec 21;188(3):1360–1370. doi: 10.4049/jimmunol.1101660

Figure 7. Bacterial clearance and innate immune cell influx is restored following adoptive transfer of CD4+ T cells into TCR αβ KO mice.

Figure 7

Brain abscesses were induced in WT, TCR αβ KO, and TCR αβ KO mice that received an adoptive transfer of 106 purified CD3+CD4+ T cells (NKT-depleted) 24 h prior to S. aureus infection (n= 4-5/group). Animals were euthanized at the indicated time points post-infection, whereupon bacterial burdens were quantitated and normalized to tissue wet weight (g), and neutrophil and macrophage infiltrates determined by FACS. Significant differences between PBS-injected TCR αβ KO mice versus TCR αβ KO animals receiving adoptively transferred T cells are denoted by asterisks (*, p < 0.05). Results represent the mean ± SEM combined from three independent experiments.