Table 5.
Cytogenetic data from bone marrow cells collected at 1 mo after exposure of male SCID/J mice to varying low doses of 137Cs γ rays, including a high dose of 1.0 Gy serving as a reference dose. Both chromatid- and chromosome-type aberrations were detected.
| Total | Total | Total | Chromatid breaks | Total | Chromosome breaks | Total | Exchanges | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dose | number of | number of | number of | (Chromosome involved) | number of | (Chromosome involved) | number of | (Both chromatid- and chromosome-types) | ||||||
| (Gy) | cells | abnormal | chromatid | Chromosome | Chromosome | Chromosome | exchanges | |||||||
| scored | cells | breaks | (1) | (2) | (3) | (nP) | breaks | (1) | (2) | (3) | (nP) | |||
| 0 | 941 | 37 | 30 | 3 | 0 | 0 | 27 | 16 | 4 | 0 | 0 | 12 | 4 | t(nP;1),t(nP;1),t(3;nP),t(nP;nP) |
| 0.05 | 393 | 10 | 4 | 1 | 0 | 1 | 2 | 5 | 0 | 0 | 0 | 5 | 1 | t*(nP;1) |
| 0.10 | 1,373 | 78 | 57 | 8 | 1 | 8 | 40 | 18 | 7 | 2 | 2 | 7 | 12 | t(1;3),recip t(1;nP),t(nP;1), t(nP;1),t(nP;1),t(nP;1), recip t(nP;2),t(nP;nP), dic(nP;nP),dic(nP;nP),ring(nP), RT(3;nP) |
| 1.00 | 518 | 49 | 27 | 7 aa | 4 | 1 | 15 | 25 | 3a | 2 | 1 | 19 | 7 | recip t(1;nP),t(2;nP),t(nP;1), t(nP;2),t(nP;2),t*(2;3), RT(1;nP) |
t Translocation (incomplete, chromosome-type), t* Translocation (incomplete chromatid-type), recip t Reciprocal translocation, RT Robertsonian translocation, dic Dicentric, ins Insertion, nP non-painted chromosome, a clones of cells with a specific type of aberration occurring on a specific chromosome found in one mouse; aa clones of cells with a specific type of aberration occurring on a specific chromosome found in two mice.