Table 6.
Cytogenetic data from bone marrow cells collected at 6 mo after exposure of male SCID/J mice to varying low doses of 137Cs γ rays, including a high dose of 1.0 Gy serving as a reference dose. Both chromatid- type and chromosome-type aberrations were detected.
| Dose (Gy) |
Total number of cells scored |
Total number of abnormal cells |
Total number of chromatid breaks |
Chromatid breaks (Chromosome involved) Chromosome |
Total number of Chromosome breaks |
Chromosome breaks (Chromosome involved) Chromosome |
Total number of exchanges |
Exchanges (Both chromatid- and chromosome-types) |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (1) | (2) | (3) | (nP) | (1) | (2) | (3) | (nP) | |||||||
| 0 | 1,693 | 95 | 43 | 10 | 2 | 1 | 30 | 30 | 7 | 0 | 5 | 18 | 17 | t(1;2),t(1;nP),t(1;nP),recip t(2;3),t(3;nP),t(nP;1),t(nP;1), t(nP;nP), t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;2), dic(nP;1),ins(nP;1),RT(nP;nP) |
| 0.05 | 948 | 32 | 19 | 2 | 4 | 2 | 11 | 21 | 5 | 7 | 1 | 8 | 8 | t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;2), t(nP;2),t(nP;2), t*(nP;2) |
| 0.10 | 1,030 | 93 | 22 | 7a | 9a | 3 | 3 | 63 | 25aa | 4 | 7 | 27 | 23 | t(1;nP),recip t(1;nP),t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;1), t(nP;1),t(nP;2),t(nP;2),t(nP;nP),t*(2;nP),t*(3;1),t*(nP;1), t*(nP;1),t*(nP;1),t*(nP;1),t*(nP;1),t*(nP;2),ins(nP;1), ins(nP;1), RT(nP;nP),RT(nP;nP) |
| 1.00 | 1,695 | 306 | 103 | 25 aa | 13 aa | 9 a | 56 | 153 | 52 aa | 14 a | 7 | 80 | 91 |
t(1;2)a,t(1;3)a,t(1;nP),recip t(1;nP), recip t(1;nP),recip t(1;nP),recip t(1;nP), recip t(1;nP),t(2;1),t(2;nP),t(2;nP), recip t(2;nP),recip t(2;nP), recip t(2;nP),t(3;1),t(nP;1),t(nP;1), t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;1),t(nP;1), t(nP;1),t(nP;1),t(nP;1),recip t(nP;1),recip t(nP;1),t(nP;2), t(nP;2),t(nP;2),t(nP;2),t(nP;2),t(nP;2),t(nP;2),t(nP;2),t(nP;2), t(nP;2),t(nP;2), recip-t(nP;2),t(nP;3),t(nP;3),t(nP;3),t(nP;3), t(nP;3),recip-t(nP;3),t(nP1),t(nP1),t(nP1),t(nP1),t(nP1), t(nP1),t(nP1),t*(nP;1),t*(nP;1),t*(nP;1),t*(nP;1),t*(nP;1), t*(nP;1),t*(nP;1),t*(nP;2),t*(nP;2),t*(nP;2),t*(nP;2),t*(nP;3), t*(nP;3),t*(nP;3),ins(1;nP),ins(2;1),ins*(2;1),ins(2;3), ins(2;nP),ins(3;nP),ins(nP;1),ins(nP;1),ins(nP;1),ins(nP;1), ins(nP;1),ins(nP;2),ins(nP;2),ins(nP;2),ins(nP;2),ins(nP;3), ins(nP;3),ins(nP;3),ins(nP;3),RT(nP;nP),RT(nP;nP) |
t Translocation (incomplete, chromosome-type), t* Translocation (incomplete chromatid-type, recip t Reciprocal translocation, RT Robertsonian translocation, dic Dicentric, ins Insertion, nP non-painted chromosome; a clones of cells with a specific type of aberration occurring on a specific chromosome found in one mouse; aa clones of cells with a specific type of aberration occurring on a specific chromosome found in two mice.