Table 3. Treatment of Tardive Dyskinesia.

Medication	Starting Daily Dose	Daily Dose Range
Slow Taper of an Offending DRBA
Dopamine-depleting medications
Tetrabenazine67	12.5–25 mg	25–200 mg (typical therapeutic dose 50–75 mg)
Reserpine86	0.25 mg	0.75–8 mg
Amantadine86	100 mg	100–300 mg
GABA agonistic medications
Clonazepam86	0.5 mg	1–4 mg
Baclofen73		20–120 mg
Valproic acid73		900–1500 mg
Anticholinergic medications
Trihexyphenidyl87	1 mg	4–20 mg
Less studied/might be effective medications (donepezil, lithium, antioxidants, zonisamide, vitamin B6, melatonin, zolpidem, propranolol)
Chemodenervation with botulinum toxin injections
Surgical treatment (deep brain stimulation)

Abbreviations: DRBA, dopamine receptor-blocking agent.