Table 4.
Antimicrobial activity of compounds 1-4.
| Extract/compound | IC50/MIC (μg/mL)
|
||||
|---|---|---|---|---|---|
| C. neoformans | E. coli | MRS | A. fumigatus | M. intracellulare | |
| A. schimperiana extr. | 3.5 | 45.0 | - | - | - |
| 1 | 1.0/2.5 | 3.5/5.0 | 5.5/10.0 | 7.5/20.0 | 1.5/5.0 |
| 2 | 10.0/20.0 | -/- | -/- | -/- | -/- |
| 3 | 1.0/2.5 | 6.5/10.0 | 6.5/10.0 | -/- | 4.0/20.0 |
| 4 | 6.0/10.0 | -/- | 20.0/- | -/- | 20.0/- |
| Amphotericin B | 0.80/1.25 | NT | NT | 0.6/1.25 | NT |
| Ciprofloxacin | NT | 0.004/0.016 | 0.09/0.50 | NT | 0.50/1.00 |
- =Not Active; NT = Not Tested; IC50 is the concentration that affords 50% inhibition of growth; MIC (Minimum Inhibitory Concentration) is the lowest test concentration that allows no detectable growth.