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Cytotoxic activity of compounds 1-4.
| Compound | IC50 (μg/mL)
|
|||||
|---|---|---|---|---|---|---|
| SK-MELa | KBb | BT-549c | SK-OV-3d | LLC-PK11e | VEROf | |
| 1 | 1.9 | 1.9 | 2.0 | 2.2 | 1.7 | 1.8 |
| 2 | 5.8 | 6.0 | 6.0 | 6.5 | 5.3 | NC |
| 3 | 2.0 | 2.3 | 2.0 | 4.8 | 2.5 | 5.3 |
| 4 | 5.7 | 5.4 | 6.0 | 6.2 | 6.0 | NC |
| Doxorubicin | 0.85 | 0.9 | 0.9 | 0.9 | <0.55 | >5 |
SK-MEL: Human malignant melanoma;
KB: Human epidermoid carcinoma;
BT-549: Human ductal carcinoma;
SK-OV-3: Human ovarycarcinoma;
LLC-PK11: Pig kidney epithelial;
VERO: Monkey kidney fibroblast.
