Table 3. Findings from genome-wide association studies of esophageal cancer in Japan and China.
| References | Sample size | Ethnic group | Loci associated with susceptibility to ESCC |
| Wang et al 200456 | 1077 ESCC cases 1733 controls |
Chinese |
PLCE1 (10q23 rs2274223; per allele OR = 1.43 [1.37–1.49]) and C20orf54 (20p13; per allele OR = 0.86 [0.82–0.90]) |
| Abnet et al 201057 | 2115 ESCC cases 3302 controls |
Chinese | PLCE1 (10q23 rs2274223; per allele OR = 1.34 [1.22–1.48]) |
| Wu et al 201158 | 2031 ESCC cases 2044 controls |
Chinese | Identified 7 susceptibility loci on chromosomes 5q11 (rs10052657; OR = 0.67 for minor variant allele), 21q22 (rs2014300; OR = 0.70 for minor variant allele), 6p21 (rs10484761), 10q23 (rs2274223), and 12q24 (rs2074356, rs11066280) (OR = 1.30–1.56 for minor variant alleles) |
| Cui et al 200924 | 1070 ESCC cases 2836 controls |
Japanese |
ALDH2 (4q21-23, rs671; per allele OR = 1.67 [1.58–1.76]) and ADH1B (12q24, rs1229984; per allele OR = 1.79 [1.69–1.88]) |
| Tanaka et al 201025 | 1071 ESCC cases 2762 controls |
Japanese |
ALDH2 (4q23, rs671; per allele OR = 1.78 [1.60–1.98]) and ADH1B (12q24.11–13, rs1229984; per allele OR = 1.82 [1.63–2.03]) |
ESCC: esophageal squamous cell carcinoma; GCA: gastric cardia cancer; OR: odds ratio; ALDH2: acetaldehyde dehydrogenase; ADH1B: alcohol dehydrogenase.