Table II. ASCs secreting IgM, IgG, or anti-Sm per spleen in nonautoimmune and autoimmune mice (×103).
| Non-Tg |
2-12H |
Non-Tg MRL/lpr |
2-12H MRL/lpr |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CD138− | CD138int | CD138− | CD138int | CD138− | CD138int | CD138high | CD138− | CD138int | CD138high | |
| IgM | 8.43 ± 2.43a (8) | 64.0 ± 1.71b (8) | 2.38 ± 2.00 (8) | 6.34 ± 1.96c (8) | 11.3 ± 2.37 (8) | 56.8 ± 18.1c (8) | 73.9 ± 27.9d (4) | 3.68 ± 0.919 (11) | 13.7 ± 7.69 (11) | 34.3 ± 13.4 (4) |
| IgG | 5.98 ± 1.22 (8) | 49.3 ± 1.81c (8) | ND | ND | 6.07 ± 2.08 (8) | 17.7 ± 4.13c (8) | 106 ± 64.5ce (4) | ND | ND | ND |
| Anti-Sm | ND | ND | 9.63 ± 6.24 (8) | 2.13 ± 0.739 (8) | ND | ND | ND | 8.23 ± 4.70 (4) | 19.8 ± 7.46 (4) | 7.53 ± 3.80 (4) |
a
Average ± SE; the number of mice analyzed for each value is provided in parentheses.
b
p < 0.01
c
p < 0.05, between CD138− and CD138int cells, or between CD138int and CD138hgh cells.
d
p < 0.01
e
p < 0.05, between CD138− and CD138high cells.