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. Author manuscript; available in PMC: 2014 Jan 1.
Published in final edited form as: J Neurosurg Pediatr. 2012 Oct 19;11(1):60–67. doi: 10.3171/2012.9.PEDS12268

Figure 3.

Figure 3

c-Myc expression in D283 Med cells is inhibited by the combination of hypoxia and intetumumab. A. Representative Western blot demonstrates decreased expression of c-Myc in DAOY cells compared to D283 Med cells and D283 Med cells grown at 1% in the presence of intetumumab. B. Expression of c-Myc in 3 separate experiments normalized to tubulin appear greater in D283 Med cells than DAOY cells although this difference was not significant due to large variance. C. Expression of c-Myc in 3 separate experiments, normalized to tubulin and to the control (21% O2 vehicle). Neither hypoxic conditions nor the presence of intetumumab significantly affected the expression of c-Myc in DAOY cells. D283 Med cells grown in 1% O2 in the presence of intetumumab had significantly less c-Myc expression compared to controls. Error bars are standard error. Clear bars = 1% O2, grey bars = 21% O2, * = P < 0.05, Int = intetumumab.