Table 1. Summary of the evidence for and against the hypothesis that the persistent residual viraemia in HAART-treated patients originates from a single source.
Persistent viraemia originated from one source (resting T-cells) | References |
• Viral genomes recovered from persistent viraemia show little variation | Bailey et al. (2006); Joos et al. (2008); Ruff et al. (2002) |
• HAART intensification does not reduce residual viraemia | Dinoso et al. (2009b); Gandhi et al. (2010); Hatano et al. (2011); McMahon et al. (2010) |
Multiple sources contribute to persistent viraemia | |
• Persistent HIV-1 infection has been found within different parts of the body | See text |
• Viral sequences distinct from those isolated from resting T-cells are found | Bailey et al. (2006); Brennan et al. (2009); Sahu et al. (2009) |
• HAART intensification increased 2-LTR circles from PBMCs | Buzón et al. (2010) |
• HAART intensification reduced HIV-1 RNA within the ileum | Yukl et al. (2010) |