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. 2013 Mar;94(Pt 3):534–542. doi: 10.1099/vir.0.047738-0

Table 2. Differentially expressed genes (n = 91) associated with HCV clearance.

Functional category Gene or gene product symbol Description Fold change P value
Cancer DYRK2 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2, transcript variant 1 2.04 0.0056
CDC14A CDC14 cell division cycle 14 homologue A (Saccharomyces cerevisiae), transcript variant 3 2.05 0.0002
HBD Haemoglobin δ 2.12 0.0025
GSTM1 Glutathione S-transferase M1, transcript variant 1 2.16 0.0355
MGST1 Microsomal glutathione S-transferase 1, transcript variant 1b 2.19 0.0190
BHLHB9 Basic helix–loop–helix domain containing, class B, 9 2.20 0.0500
CTAGE5 CTAGE family, member 5, transcript variant 4 2.25 0.0036
PRPH Peripherin 2.27 0.0317
SF1 Splicing factor 1, transcript variant 4 2.30 0.0449
SMPD3 Sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) 2.38 0.0210
GSTM3 Glutathione S-transferase M3 (brain) 2.44 0.0008
FOLR3 Folate receptor 3 (γ) 2.45 0.0461
HTRA1 Htra serine peptidase 1 2.55 0.0441
TFF3 Trefoil factor 3 (intestinal) 2.68 0.0348
HRK Harakiri, BCL2 interacting protein (contains only BH3 domain) 2.82 0.0375
ALOX15 Homo sapiens arachidonate 15-lipoxygenase 2.96 0.0171
OLIG2 Oligodendrocyte lineage transcription factor 2 2.96 0.0010
AMACR α-Methylacyl-coa racemase, transcript variant 1 0.50 0.0263
PARP10 Poly (ADP-ribose) polymerase family, member 10 0.49 0.0012
CXCR7 Chemokine (C-X-C motif) receptor 7, transcript variant 1 0.48 0.0307
CXCR7 Chemokine (C-X-C motif) receptor 7 0.50 0.0004
HOXB2 Homeobox B2 0.47 0.0279
PARP9 Poly(ADP-ribose) polymerase family, member 9 0.46 0.0019
OSM Oncostatin M 0.44 0.0126
RASSF5 Ras association (ralgds/AF-6) domain family member 5, transcript variant 3 0.32 0.0321
PPP2R3B Protein phosphatase 2 (formerly 2A), regulatory subunit B′′, β, transcript variant 2 0.25 0.0338
GATA2 GATA binding protein 2 0.23 0.0085
Immunity CLC Charcot-Leyden crystal protein 2.12 0.0065
IL5RA Interleukin 5 receptor, α, transcript variant 6 2.13 0.0126
EMR4 Egf-like module containing, mucin-like, hormone receptor-like 4 4.14 0.0002
CCL23 Chemokine (C-C motif) ligand 23, transcript variant ckβ8-1 6.26 0.0440
PLSCR1 Phospholipid scramblase 1 0.50 0.0456
CD8B CD8b molecule, transcript variant 5 0.50 0.0006
TRIM5 Tripartite motif-containing 5, transcript variant α 0.49 0.0060
TRIM22 Tripartite motif-containing 22 0.48 0.0062
CD38 CD38 molecule 0.48 0.0437
FCGR1B Fc fragment of igg, high affinity Ib, receptor (CD64), transcript variant 2 0.48 0.0057
IFI35 Interferon-induced protein 35 0.47 0.0059
IFIT2 Interferon-induced protein with tetratricopeptide repeats 2 0.47 0.0276
IRF7 Interferon regulatory factor 7, transcript variant b 0.43 0.0022
IRF7 Interferon regulatory factor 7, transcript variant b 0.49 0.0004
DLL1 δ-like 1 (Drosophila) 0.43 0.0491
EVI2A Ecotropic viral integration site 2A, transcript variant 1 0.40 0.0252
MX1 Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) 0.40 0.0086
C1QB Complement component 1, q subcomponent, B chain 0.35 0.0453
OAS1 2′,5′-Oligoadenylate synthetase 1, 40/46 kDa, transcript variant 2 0.21 0.0010
OAS1 2′,5′-Oligoadenylate synthetase 1, 40/46 kDa, transcript variant 3 0.45 0.0371
TNFRSF18 Tumour necrosis factor receptor superfamily, member 18, transcript variant 3 0.31 0.0028
IFIT3 Interferon-induced protein with tetratricopeptide repeats 3 0.24 0.0051
IFIT3 Interferon-induced protein with tetratricopeptide repeats 3 0.34 0.0003
IFIT3 Interferon-induced protein with tetratricopeptide repeats 3 0.36 0.0002
IFI6 Interferon, α-inducible protein 6, transcript variant 2 0.29 0.0034
MS4A2 Membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; β polypeptide) 0.27 0.0046
ISG15 ISG15 ubiquitin-like modifier 0.23 0.0280
IFIT1 Interferon-induced protein with tetratricopeptide repeats 1, transcript variant 2 0.23 0.0388
SERPING1 Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1, transcript variant 2 0.19 0.0233
TMEM176B Transmembrane protein 176B 0.16 0.0012
TMEM176A Transmembrane protein 176A 0.10 0.0005
Other SERINC5 Serine incorporator 5 2.04 0.0214
PRSS33 Protease, serine, 33 2.04 0.0059
ZNF493 Zinc-finger protein 493, transcript variant 3 2.04 0.0088
GYPE Glycophorin E, transcript variant 1 2.44 0.0002
ZNF121 Zinc-finger protein 121 2.69 0.0159
NEBL Nebulette, transcript variant 1 2.73 0.0147
GYPB Glycophorin B (MNS blood group) 2.78 0.0001
KCNMB4 Potassium large conductance calcium-activated channel, subfamily M, β member 4 2.97 0.0300
NAV1 Neuron navigator 1 5.92 0.0402
TMEM100 Transmembrane protein 100, transcript variant 2 7.76 0.0300
GBP4 Guanylate binding protein 4 0.49 0.0079
LFNG LFNG O-fucosylpeptide 3-β-N-acetylglucosaminyltransferase, transcript variant 2 0.49 0.0322
RGPD2 RANBP2-like and GRIP domain containing 2 (RGPD2) XM_001134112 XM_001134114 XM_001134116 0.45 0.0279
RPS6KA2 Ribosomal protein S6 kinase, 90 kDa, polypeptide 2, transcript variant 2 0.45 0.0216
ARHGAP12 Rho GTPase activating protein 12 0.44 0.0208
DHRS9 Dehydrogenase/reductase (SDR family) member 9, transcript variant 2 0.44 0.0431
GBP1 Guanylate binding protein 1, interferon-inducible, 67 kDa 0.42 0.0008
HERC5 Hect domain and RLD 5 0.40 0.0107
GCH1 GTP cyclohydrolase 1, transcript variant 3 0.39 0.0106
LMTK2 Lemur tyrosine kinase 2 0.39 0.0340
SLC34A1 Solute carrier family 34 (sodium phosphate), member 1 0.37 0.0260
OASL 2′-5′-Oligoadenylate synthetase-like, transcript variant 1 0.30 0.0026
OASL 2′-5′-Oligoadenylate synthetase-like, transcript variant 2 0.36 0.0102
TBRG4 Transforming growth factor β regulator 4, transcript variant 1 0.33 0.0280
HDC Histidine decarboxylase 0.31 0.0459
GPRC5C G protein-coupled receptor, family C, group 5, member C, transcript variant 2 0.22 0.0369
Undefined PHF20L1 PHD finger protein 20-like 1, transcript variant 2 2.01 0.0104
RUNDC2A RUN domain containing 2A 2.02 0.0148
GTSF1 Gametocyte specific factor 1 2.07 0.0003
MGC26718 Similar to ankyrin repeat domain 20A 2.32 0.0342
KIAA0367 Kiaa0367 2.78 0.0074
C17ORF97 Chromosome 17 open reading frame 97 3.42 0.0117
MOBK1B MOB1, Mps One Binder kinase activator-like 1B (yeast) 0.47 0.0327
FAM26F Family with sequence similarity 26, member F 0.43 0.0025
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.43 0.0295
CPA3 Carboxypeptidase A3 (mast cell) 0.38 0.0478
BATF2 Basic leucine zipper transcription factor, ATF-like 2 0.35 0.0218
SPRYD5 SPRY domain containing 5 0.29 0.0062
SAMD8 Sterile α motif domain containing 8 0.22 0.0462