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. 2013 Feb;94(Pt 2):432–442. doi: 10.1099/vir.0.046110-0

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Fig. 3. — Distribution of PrP^CWD in the brain of ferrets inoculated by mucosal routes. Distribution of PrP^CWD was compared in the brains of ferrets inoculated by the i.g. (no. 521) versus n.ph. (nos 540 and 532) route. Brainstem (BS), cerebellar peduncle (CP), ventral midbrain pons (VMP), dorsal midbrain colliculus (DMC), thalamus/hypothalamus (THT) and olfactory bulb (OLF) accumulated PrP^CWD. PrP^CWD was absent or less prominent in cerebellar folia (CF), caudal (CHC) and forward hippocampus (HC), posterior cortex white matter (PCW) and grey matter (PCG), cerebral cortex white matter (CCW) and grey matter (CCG) and lateral olfactory tract (LOT). Proteinase K (PK) digestion was carried out (+) or not (−), as indicated. PrP^CWD (PK+) and PrP^C (PK−) comparisons were based on 800 and 200 µg tissue equivalents (TEs), respectively.