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. 2013 Feb 11;54(4):727–735. doi: 10.1093/jrr/rrt006

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© The Author 2013. Published by Oxford University Press on behalf of The Japan Radiation Research Society and Japanese Society for Therapeutic Radiology and Oncology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 2. — Gd-enhanced T1-weighted MR images. (A) Breast cancer brain metastases in a 55-year-old female. A tectum tumor treated with a marginal dose of 30 Gy in three fractions at 60% isodose (left). A significant tumor response and no adverse imaging effects found 11 months after three-fraction CyberKnife radiotherapy (right). (B) Lung cancer brain metastasis in a 64-year-old male. A tumor in the speech area with perifocal edema treated with a marginal dose of 25 Gy in three fractions at 60% isodose (left). A tumor response found 1 year after three-fraction radiotherapy (right). (C) Breast cancer brain metastasis in a 37-year-old female. A tumor in the sensory area with perifocal edema treated with a marginal dose of 30 Gy in three fractions at a 59% isodose (left). A tumor response was found 11 months after treatment. However, both clinical and radiological deterioration were noted (center) and surgical resection was required after osmo-steroid therapy. The surgical specimen confirmed as radiation necrosis and the hemiparesis improved after surgery (right).