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. 2013 Feb 11;54(4):727–735. doi: 10.1093/jrr/rrt006

Fig. 3.

Fig. 3.

The risk evaluation of adverse effects (brain edema and radiation necrosis).

The V14 of 159 brain metastases plotted in relation to the marginal doses administered in three-fraction CyberKnife radiotherapy. Symptomatic brain edema developed in six patients (triangle) and radiation necrosis requiring surgical resection appeared in three patients (circle). Kjellberg's 5% necrosis risk line [10] was converted and then drawn for three-fraction radiotherapy (dotted line).