Fig. 2.

(a) A schematic diagram of parental MARV GP. SP, Signal peptide; RBR, putative receptor-binding region; MLR, mucin-like region; FP, fusion peptide; TM, transmembrane domain. The furin-cleavage site and a disulphide bond between the GP1 and GP2 subunits are indicated by the arrow and line, respectively. (b) Point mutations found in the MARV GPs of escape variants selected by mAb AGP127-8 or MGP72-17. The substituted amino acid residues and furin-recognition motif are shown in boldface and underlined, respectively. The putative epitopes of mAbs AGP127-8 and MGP72-17 (details in Fig. 4) are shown in the box. (c) The deletions found in the MARV GPs of escape variants selected by mAb MGP72-17. Deleted regions are highlighted with lines. The mucin-like region is shown in grey.