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. 2013 May 23;14(6):10761–10790. doi: 10.3390/ijms140610761

Figure 2.

Figure 2

A sequence of events associated with Y845 phosphorylation of EGFR. Phosphorylation of EGFR on Y845 is usually catalyzed by Src and other Src family PTKs, and in some cases, is mediated by a non-Src family PTK or autophosphorylation of EGFR. The Y845 phosphorylation modulates a variety of cellular functions through the activation of several downstream events. It can also be used as a diagnostic marker of cancer treatments and for other applications that harness the phospho-Y845 signal into an antibody-, peptide-, or some other materials-based biological mimetics, as described in the main text.