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Development of stratified epidermis in mouse embryos. The epidermis is derived from embryonic surface ectoderm. After epidermal commitment, the surface ectoderm becomes the embryonic epidermal basal layer, which subsequently gives rise to the intermediate layer, spinous layer, granular layer and cornified layer. Different layers are labeled in different colors, with their specific markers annotated. NT, neural tube; Me, mesoderm; SE, surface ectoderm.
