Table 2.

Univariate analysis by Cox proportional hazards model of clinicopathological parameters on cancer-specific and overall survival in 278 ccRCC patients.

		Hazard Ratio (95% CI)
Variable	Categories	Overall survival	p-value	Cancer specific survival	p-value
Age	±median	1.69 (1.15–2.48)	0.007	1.00 (0.62–1.64)	0.97
Gender	female vs. male	0.90 (0.59–1.26)	0.6	0.58 (0.31–1.07)	0.08
T-stage	T1/2 vs. T3/4	4.32 (2.93–6.37)	<0.0001	9.62 (5.20–17.77)	<0.0001
N-stage	N0 vs. N1/2	3.22 (1.68–6.19)	<0.0001	5.01 (2.50–10.20)	<0.0001
M-stage	M0 vs. M1	5.51 (3.59–8.47)	<0.0001	9.57 (5.65–16.19)	<0.0001
Nuclear Grade	G1/2 vs. G3/4	3.80 (2.52–5.72)	<0.0001	6.78 (4.13–11.13)	<0.0001
Tumor Necrosis	yes vs. no	1.80 (1.24–2.60)	0.002	2.81 (1.70–4.66)	<0.0001
Sarcomatoid Differentiation	yes vs. no	4.60 (2.72–7.76)	<0.0001	7.36 (4.08–13.25)	<0.0001
Vascular Invasion	yes vs. no	3.10 (2.13–4.50)	<0.0001	5.67 (3.39–9.50)	<0.0001
Perinephric Invasion	yes vs. no	2.53(1.23–4.11)	0.008	2.20 (1.00–4.84)	0.5
Sinus Invasion	yes vs. no	2.29 (1.46–3.58)	<0.0001	2.78 (1.59–4.85)	<0.0001
Wnt1 Score tumor	±mean	1.18 (0.81–1.73)	0.4	0.95 (0.57–1.58)	0.84
β-catenin Score membrane tumor	±mean	1.26 (0.84–1.89)	0.27	1.35 (0.79–2.30)	0.28
β-catenin Score cytoplasm tumor	±mean	1.75 (1.04–2.94)	0.035	2.26 (1.20–4.27)	0.012