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. 2013 May 27;14(6):11171–11189. doi: 10.3390/ijms140611171

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© 2013 by the authors; licensee MDPI, Basel, Switzerland

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Mean fold changes of the expression levels of endo-miRNA target transcripts following the transfection of exo-miRNAs. HeLa cells were transfected with each of fifteen exo-miRNA duplexes, log₂ mean differential fold changes of the expression levels of seed-matched target genes of each of the top 20 endo-miRNAs were calculated. Data were shown with respect to transfected exo-miRNAs, miR-7b (A); miR-1 (B); miR-21 (C); miR-22 (D); miR-28 (E); miR-30c-1 (F); miR-186 (G); miR-199b (H); miR-200b (I); miR-330 (J); miR-335 (K); miR-346 (L); miR-466 (M); miR-574 (N); miR-3126 (O); and their averaged values were shown in (P). Target genes of different endo-miRNAs are increased by exo-miRNAs in approximately comparable levels. The individual data are shown in Figures S2–S21. Data represent the mean ± SE (*p < 0.05).

Mean fold changes of the expression levels of endo-miRNA target transcripts following the transfection of exo-miRNAs. HeLa cells were transfected with each of fifteen exo-miRNA duplexes, log₂ mean differential fold changes of the expression levels of seed-matched target genes of each of the top 20 endo-miRNAs were calculated. Data were shown with respect to transfected exo-miRNAs, miR-7b (A); miR-1 (B); miR-21 (C); miR-22 (D); miR-28 (E); miR-30c-1 (F); miR-186 (G); miR-199b (H); miR-200b (I); miR-330 (J); miR-335 (K); miR-346 (L); miR-466 (M); miR-574 (N); miR-3126 (O); and their averaged values were shown in (P). Target genes of different endo-miRNAs are increased by exo-miRNAs in approximately comparable levels. The individual data are shown in Figures S2–S21. Data represent the mean ± SE (*p < 0.05).