Table S6.
Specific enriched GO terms of each miRNA-regulated PINs. Genes annotated with the specific GO term in the PIN were also listed in this table. Adj. p-value: multiple-test adjusted p-value calculated by the method described in the work of Benjamini and Yekutieli [48].
| MIMAT0002856(hsa-miR-520d-3p) | ||
|---|---|---|
|
| ||
| GO term | Genes | Adj. p-value |
| GO:0007169, Transmembrane receptor protein tyrosine kinase signaling pathway | SH3KBP1, HDAC2, RET, ABI1, LYN, GRB2, SORBS1, CLTC, CLTA, CDC42, CASP9, RAF1, SRC, AP2A1, AP2B1, MAPK3, ARHGEF7, PRKCA, RPS6, PRKAR2B, MAPK1, ARHGEF6, CDK1, SH3GL2, EIF4G1, HDAC1, ECT2, MKNK1, CASP3, PRKACA, ADRB2, PRKAR2A, EIF4B, SHC1, RAC1 | 2.77 × 10−29 |
|
| ||
| GO:0048011, Nerve growth factor receptor signaling pathway | HDAC2, GRB2, CLTC, CLTA, CASP9, RAF1, SRC, AP2A1, AP2B1, MAPK3, ARHGEF7, PRKCA, PRKAR2B, MAPK1, ARHGEF6, CDK1, SH3GL2, HDAC1, ECT2, CASP3, PRKACA, PRKAR2A, SHC1, RAC1 | 5.09 × 10−24 |
|
| ||
| GO:0007173, Epidermal growth factor receptor signaling pathway | SH3KBP1, GRB2, CLTC, CLTA, CDC42, CASP9, RAF1, SRC, AP2A1, AP2B1, MAPK3, ARHGEF7, PRKCA, PRKAR2B, MAPK1, CDK1, SH3GL2, PRKACA, PRKAR2A, SHC1 | 2.96 × 10−22 |
|
| ||
| GO:0043067, Regulation of programmed cell death | HDAC2, STK17B, ESR1, ABL1, LYN, TP53, GABRB3, PAK2, LCK, CASP9, RAF1, PLK1, ARHGEF7, PRKCA, RPS6, SH3RF1, MAPK1, IFT57, ARHGAP10, ARHGEF6, CDK1, APAF1, HDAC1, ECT2, CASP3, SOX10, EP300, ARAF, TFAP2A, ADRB2, HCK, KLHL20, CASP8, HIP1, RAC1 | 4.76 × 10−19 |
|
| ||
| GO:0042058, Regulation of epidermal growth factor receptor signaling pathway | SH3KBP1, ESR1, GRB2, CLTC, CLTA, CDC42, AP2A1, AP2B1, ARHGEF7, SH3GL2, SHC1 | 2.36 × 10−12 |
|
| ||
| GO:0008543, Fibroblast growth factor receptor signaling pathway | GRB2, CASP9, RAF1, SRC, MAPK3, PRKCA, PRKAR2B, MAPK1, CDK1, MKNK1, PRKACA, PRKAR2A, SHC1 | 2.39 × 10−12 |
|
| ||
| GO:0043068, Positive regulation of programmed cell death | STK17B, ABL1, LYN, TP53, LCK, CASP9, ARHGEF7, PRKCA, RPS6, SH3RF1, MAPK1, ARHGEF6, APAF1, ECT2, CASP3, EP300, TFAP2A, ADRB2, CASP8, HIP1, RAC1 | 3.09 × 10−12 |
|
| ||
| GO:0010942, Positive regulation of cell death | STK17B, ABL1, LYN, TP53, LCK, CASP9, ARHGEF7, PRKCA, RPS6, SH3RF1, MAPK1, ARHGEF6, APAF1, ECT2, CASP3, EP300, TFAP2A, ADRB2, CASP8, HIP1, RAC1 | 4.49 × 10−12 |
|
| ||
| GO:0006917, Induction of apoptosis | STK17B, ABL1, TP53, LCK, CASP9, ARHGEF7, PRKCA, SH3RF1, MAPK1, ARHGEF6, APAF1, ECT2, CASP3, EP300, CASP8, HIP1, RAC1 | 6.91 × 10−11 |
|
| ||
| GO:0012502, Induction of programmed cell death | STK17B, ABL1, TP53, LCK, CASP9, ARHGEF7, PRKCA, SH3RF1, MAPK1, ARHGEF6, APAF1, ECT2, CASP3, EP300, CASP8, HIP1, RAC1 | 7.42 × 10−11 |
|
| ||
| GO:0042059, Negative regulation of epidermal growth factor receptor signaling pathway | SH3KBP1, GRB2, CLTC, CLTA, CDC42, AP2A1, AP2B1, ARHGEF7, SH3GL2 | 8.63 × 10−11 |
|
| ||
| GO:0015630, Microtubule cytoskeleton | STMN1, SORBS1, SMAD4, CLTC, CDC42, LCK, RACGAP1, PLK1, PRKAR2B, YES1, MAPK1, IFT57, CDK1, ECT2, PRKACA, RB1, EP300, CCNB1, CHAF1B, TFAP2A, CASP8, PRKAR2A | 4.75 × 10−10 |
|
| ||
| GO:0060548, Negative regulation of cell death | HDAC2, ESR1, TP53, SMAD4, RAF1, PLK1, PRKCA, RPS6, SH3RF1, CDK1, HDAC1, CASP3, SOX10, ARAF, TFAP2A, HCK, KLHL20 | 6.27 × 10−8 |
|
| ||
| GO:0008286, Insulin receptor signaling pathway | GRB2, SORBS1, RAF1, MAPK3, RPS6, MAPK1, CDK1, EIF4G1, EIF4B, SHC1 | 2.15 × 10−7 |
|
| ||
| GO:0043069, Negative regulation of programmed cell death | HDAC2, ESR1, TP53, RAF1, PLK1, PRKCA, RPS6, SH3RF1, CDK1, HDAC1, CASP3, SOX10, ARAF, TFAP2A, HCK, KLHL20 | 3.13 × 10−7 |
|
| ||
| GO:0008284, Positive regulation of cell proliferation | HDAC2, ESR1, LYN, CDC42, E2F1, PRKCA, MAPK1, CDK1, RHOG, HDAC1, NCK1, SOX10, CCNB1, ADRB2, HCK, SHC1 | 8.34 × 10−7 |
|
| ||
| GO:0051988, Regulation of attachment of spindle microtubules to kinetochore | CDC42, RACGAP1, ECT2, CCNB1 | 3.27 × 10−5 |
|
| ||
| GO:0008629, Induction of apoptosis by intracellular signals | ABL1, TP53, CASP9, APAF1, CASP3, EP300, CASP8 | 5.83 × 10−5 |
|
| ||
| MIMAT0002820(hsa-miR-497-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0043067, Regulation of programmed cell death | ESR1, MEN1, ABL1, HIPK3, PPARGC1A, SIAH1, SH3RF1, PAK2, LCK, MED1, PPARG, CBX4, ARHGEF7, YWHAB, RXRA, ACVR1, MAPK1, CASP3, CASP6, AR, PTPRF, MDM2, BRCA1, MLH1, RAB27A, PIAS4, FAF1, RAC1, VHL, SKI, NR4A1, LYN, TP53, PSMC2, GATA1, GATA6, GATA3, RAF1, CDKN1B, PLK1, PSMD11, HOXA13, RPS6, ESR2, ARHGAP10, ARHGEF6, SMAD3, SKIL, RYR2, PSEN1, HCK, TRAF2 | 2.67 × 10−25 |
|
| ||
| GO:0043068, Positive regulation of programmed cell death | MEN1, ABL1, SIAH1, SH3RF1, LCK, PPARG, ARHGEF7, YWHAB, RXRA, MAPK1, CASP3, CASP6, PTPRF, BRCA1, MLH1, RAB27A, PIAS4, FAF1, RAC1, NR4A1, LYN, TP53, GATA6, CDKN1B, HOXA13, RPS6, ESR2, ARHGEF6, SMAD3, RYR2, PSEN1, TRAF2 | 1.74 × 10−17 |
|
| ||
| GO:0010942, Positive regulation of cell death | MEN1, ABL1, SIAH1, SH3RF1, LCK, PPARG, ARHGEF7, YWHAB, RXRA, MAPK1, CASP3, CASP6, PTPRF, BRCA1, MLH1, RAB27A, PIAS4, FAF1, RAC1, NR4A1, LYN, TP53, GATA6, CDKN1B, HOXA13, RPS6, ESR2, ARHGEF6, SMAD3, RYR2, PSEN1, TRAF2 | 3.08 × 10−17 |
| GO:0008285, Negative regulation of cell proliferation | MEN1, MED1, PPARG, RXRA, CASP3, AR, PTPRF, VDR, VHL, SKI, LYN, TP53, TOB1, GATA1, GATA3, RAF1, HNF4A, CDKN1B, BRD7, MED25, ESR2, ABI1, SMAD1, SMAD2, SMAD3, SMAD4, SOX7 | 3.85 × 10−14 |
|
| ||
| GO:0015629, Actin cytoskeleton | ABL1, SORBS1, FLNA, SEPT7, ANLN, MACF1, HAP1, SH3PXD2A, IQGAP2, BRCA1, ACTC1, ACTA1, MYL2, MYLK, SORBS2, ARPC4, ARPC5, ACTR2, ACTR3, ARPC1B, WASF1, WASF2, HCK | 2.52 × 10−13 |
|
| ||
| GO:0006917, Induction of apoptosis | ABL1, SH3RF1, LCK, PPARG, ARHGEF7, YWHAB, MAPK1, CASP3, CASP6, BRCA1, MLH1, RAB27A, RAC1, NR4A1, TP53, CDKN1B, ARHGEF6, SMAD3, RYR2, PSEN1, TRAF2 | 9.69 × 10−11 |
|
| ||
| GO:0012502, Induction of programmed cell death | ABL1, SH3RF1, LCK, PPARG, ARHGEF7, YWHAB, MAPK1, CASP3, CASP6, BRCA1, MLH1, RAB27A, RAC1, NR4A1, TP53, CDKN1B, ARHGEF6, SMAD3, RYR2, PSEN1, TRAF2 | 1.06 × 10−10 |
|
| ||
| GO:0007178, Transmembrane receptor protein serine/threonine kinase signaling pathway | ACVR1, SMURF2, SKI, GDF6, BMP6, ZNF8, GATA4, HNF4A, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5, RYR2 | 1.22 × 10−10 |
|
| ||
| GO:0007169, Transmembrane receptor protein tyrosine kinase signaling pathway | SORBS1, CDC42, SRC, MAPK3, ARHGEF7, YWHAB, MAPK1, SH3GL2, CASP3, MDM2, EIF4G1, RAC1, SH3KBP1, NR4A1, LYN, GRB2, RAF1, CDKN1B, RPS6, ABI1, ARHGEF6, MKNK1, PSEN1, EIF4B | 1.67 × 10−10 |
|
| ||
| GO:0090092, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | MEN1, ACVR1, SMURF2, SKI, GDF6, TP53, BMP6, GATA4, GATA6, HOXA13, SMAD2, SMAD3, SMAD4, SKIL | 7.51 × 10−10 |
|
| ||
| GO:0030509, BMP signaling pathway | ACVR1, SMURF2, SKI, GDF6, BMP6, ZNF8, SMAD1, SMAD4, SMAD5, RYR2 | 3.25 × 10−9 |
|
| ||
| GO:0060548, Negative regulation of cell death | ESR1, HIPK3, PPARGC1A, SH3RF1, MED1, CBX4, ACVR1, CASP3, AR, MDM2, VHL, TP53, GATA1, GATA6, GATA3, RAF1, CDKN1B, PLK1, RPS6, SMAD3, SMAD4, PSEN1, HCK | 7.88 × 10−9 |
|
| ||
| GO:0007173, Epidermal growth factor receptor signaling pathway | CDC42, SRC, MAPK3, ARHGEF7, YWHAB, MAPK1, SH3GL2, MDM2, SH3KBP1, NR4A1, GRB2, RAF1, CDKN1B | 9.22 × 10−9 |
|
| ||
| GO:0030521, Androgen receptor signaling pathway | PPARGC1A, MED14, MED1, AR, BRCA1, MED12, PIAS1, RAN, NR1I3 | 1.42 × 10−8 |
|
| ||
| GO:0043069, Negative regulation of programmed cell death | ESR1, HIPK3, PPARGC1A, SH3RF1, MED1, CBX4, ACVR1, CASP3, AR, MDM2, VHL, TP53, GATA1, GATA6, GATA3, RAF1, CDKN1B, PLK1, RPS6, SMAD3, PSEN1, HCK | 2.44 × 10−8 |
|
| ||
| GO:0048011, Nerve growth factor receptor signaling pathway | SRC, MAPK3, ARHGEF7, YWHAB, MAPK1, SH3GL2, CASP3, MDM2, RAC1, NR4A1, GRB2, RAF1, CDKN1B, ARHGEF6, PSEN1 | 2.64 × 10−8 |
|
| ||
| GO:0032956, Regulation of actin cytoskeleton organization | ABL1, LRP1, ARPC4, ARPC5, ACTR3, ARPC1B, SMAD3, NCK1, SORBS3, HCK, LIMK1 | 6.42 × 10−6 |
|
| ||
| GO:0008543, Fibroblast growth factor receptor signaling pathway | SRC, MAPK3, YWHAB, MAPK1, MDM2, NR4A1, GRB2, RAF1, CDKN1B, MKNK1 | 9.06 × 10−6 |
|
| ||
| GO:0042059, Negative regulation of epidermal growth factor receptor signaling pathway | CDC42, ARHGEF7, SH3GL2, PTPRF, SH3KBP1, GRB2, PSEN1 | 1.11 × 10−5 |
|
| ||
| GO:0042058, Regulation of epidermal growth factor receptor signaling pathway | ESR1, CDC42, ARHGEF7, SH3GL2, PTPRF, SH3KBP1, GRB2, PSEN1 | 1.17 × 10−5 |
|
| ||
| GO:0007179, Transforming growth factor beta receptor signaling pathway | ACVR1, SMURF2, SKI, SMAD1, SMAD2, SMAD3, SMAD4, SMAD5 | 1.67 × 10−5 |
|
| ||
| GO:0015630, Microtubule cytoskeleton | STMN1, RIF1, SORBS1, CDC42, LCK, RACGAP1, YES1, YWHAB, MAPK1, SEPT7, KIF23, CDC16, MACF1, BRCA1, FEZ1, NCOR1, PLK1, CHD3, SMAD4, CEP350, CDC27, PSEN1 | 2.14 × 10−5 |
|
| ||
| GO:0017015, Regulation of transforming growth factor beta receptor signaling pathway | MEN1, SMURF2, SKI, TP53, SMAD2, SMAD3, SMAD4, SKIL | 2.30 × 10−5 |
|
| ||
| GO:0070302, Regulation of stress-activated protein kinase signaling cascade | MEN1, ZEB2, HIPK3, SH3RF1, CDC42, MAPK3, MAPK1, LYN, NCOR1, TRAF2 | 2.74 × 10−5 |
|
| ||
| GO:0001959, Regulation of cytokine-mediated signaling pathway | HSP90AB1, MED1, PPARG, PTPRF, NR1H2, PIAS1, IL36RN, HIPK1 | 6.35 × 10−5 |
|
| ||
| GO:0008284, Positive regulation of cell proliferation | ESR1, CDC42, MED1, RARA, MAPK1, AR, MDM2, NR4A1, LYN, FZR1, BMP6, GATA1, GATA4, GATA6, CDKN1B, NCK1, HCLS1, HCK | 7.29 × 10−5 |
|
| ||
| MIMAT0000423(hsa-miR-125b-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0043067, Regulation of programmed cell death | HMGA2, PML, PRNP, FGF2, XRCC4, BRCA1, IGFBP3, HDAC3, CTNNB1, CD5, CDK1, NKX2-5, MEF2C, PRKCI, CASP2, PSMA4, PSMA3, CFDP1, CAV1, FAF1, YWHAB, HIF1A, RELA, TCF7L2, TNFSF12, PSEN2, TP53, TOP2A, TNFRSF4, BID, MYC, JUN, OGT, CDKN1A, HOXA13, RNF7, PPP2R4, HDAC2, HDAC1, SNCA, PTEN, NFKBIA, IFI16, NOL3, TRAF2, HSP90B1 | 4.56 × 10−24 |
|
| ||
| GO:0060548, Negative regulation of cell death | HMGA2, PRNP, FGF2, XRCC4, HDAC3, CTNNB1, CDK1, NKX2-5, MEF2C, PRKCI, CFDP1, HIF1A, RELA, TCF7L2, PSEN2, TP53, TNFRSF4, MYC, JUN, CDKN1A, RNF7, HDAC2, HDAC1, SNCA, PTEN, MGMT, NFKBIA, NOL3, HSP90B1 | 8.04 × 10−17 |
|
| ||
| GO:0008284, Positive regulation of cell proliferation | HMGA2, FGF2, XRCC4, CDC25B, CTNNB1, EGR1, AGGF1, CDK1, NKX2-5, MEF2C, PRKCI, IRS1, HIF1A, RELA, HCLS1, TNFSF12, ARNT, PTPRC, TNFSF4, TNFRSF4, MYC, JUN, FGF1, CDKN1A, HDAC2, HDAC1, NOLC1, PTEN | 2.20 × 10−15 |
| GO:0043069, Negative regulation of programmed cell death | HMGA2, PRNP, XRCC4, HDAC3, CTNNB1, CDK1, NKX2-5, MEF2C, PRKCI, CFDP1, HIF1A, RELA, TCF7L2, PSEN2, TP53, TNFRSF4, MYC, JUN, CDKN1A, RNF7, HDAC2, HDAC1, SNCA, PTEN, NFKBIA, NOL3, HSP90B1 | 3.62 × 10−15 |
|
| ||
| GO:0043068, Positive regulation of programmed cell death | HMGA2, PML, BRCA1, IGFBP3, CTNNB1, CD5, MEF2C, PRKCI, CASP2, CAV1, FAF1, YWHAB, TNFSF12, PSEN2, TP53, TOP2A, BID, JUN, OGT, CDKN1A, HOXA13, RNF7, PPP2R4, PTEN, IFI16, TRAF2 | 4.51 × 10−14 |
|
| ||
| GO:0010942, Positive regulation of cell death | HMGA2, PML, BRCA1, IGFBP3, CTNNB1, CD5, MEF2C, PRKCI, CASP2, CAV1, FAF1, YWHAB, TNFSF12, PSEN2, TP53, TOP2A, BID, JUN, OGT, CDKN1A, HOXA13, RNF7, PPP2R4, PTEN, IFI16, TRAF2 | 7.15 × 10−14 |
|
| ||
| GO:0006916, Anti-apoptosis | PRNP, HDAC3, CDK1, NKX2-5, MEF2C, PRKCI, CFDP1, RELA, TCF7L2, PSEN2, RNF7, HDAC1, SNCA, NFKBIA, NOL3, HSP90B1 | 1.25 × 10−10 |
|
| ||
| GO:0008285, Negative regulation of cell proliferation | SERPINF1, SRF, PML, PRNP, FGF2, CSNK2B, IGFBP3, CTNNB1, CAV1, HMGA1, VDR, CDH5, HSF1, COL18A1, TP53, MYC, JUN, CDKN1A, PAK1, PTEN | 2.08 × 10−9 |
|
| ||
| GO:0015630, Microtubule cytoskeleton | STMN1, KIF1C, RANGAP1, CDC25B, BRCA1, HDAC3, CTNNB1, PIN4, HSPH1, RANBP9, CDK1, SPTAN1, YWHAQ, DVL1, FKBP4, YWHAB, CCDC85B, MAPT, PSEN2, TOP2A, SPIB, MYC, OGT, APEX1, PAFAH1B1 | 2.24 × 10−9 |
|
| ||
| GO:0048011, Nerve growth factor receptor signaling pathway | HDAC3, CDK1, MEF2C, PRKCI, CASP2, IRS1, YWHAB, RELA, PSEN2, HDAC2, HDAC1, PTEN, ATF1, NFKBIA | 1.99 × 10−8 |
|
| ||
| GO:0050678, Regulation of epithelial cell proliferation | SERPINF1, PGR, FGF2, CTNNB1, AGGF1, CAV1, HIF1A, TNFSF12, ARNT, MYC, JUN, FGF1, PTEN | 3.41 × 10−8 |
|
| ||
| GO:0007169, Transmembrane receptor protein tyrosine kinase signaling pathway | FGF2, HDAC3, CDK1, MEF2C, PRKCI, CASP2, IRS1, FIBP, PTPN1, YWHAB, RELA, PSEN2, FGF1, HDAC2, HDAC1, PTEN, ATF1, NFKBIA, EIF4EBP1 | 6.39 × 10−8 |
| GO:0006917, Induction of apoptosis | PML, BRCA1, CD5, CASP2, CAV1, YWHAB, TNFSF12, PSEN2, TP53, BID, OGT, CDKN1A, RNF7, PTEN, IFI16, TRAF2 | 1.68 × 10−7 |
|
| ||
| GO:0012502, Induction of programmed cell death | PML, BRCA1, CD5, CASP2, CAV1, YWHAB, TNFSF12, PSEN2, TP53, BID, OGT, CDKN1A, RNF7, PTEN, IFI16, TRAF2 | 1.81 × 10−7 |
|
| ||
| GO:0035666, TRIF-dependent toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 2.40 × 10−6 |
|
| ||
| GO:0034138, Toll-like receptor 3 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 2.71 × 10−6 |
|
| ||
| GO:0051693, Actin filament capping | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 3.43 × 10−6 |
| GO:0002756, MyD88- independent toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 3.82 × 10−6 |
|
| ||
| GO:0034134, Toll-like receptor 2 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 5.33 × 10−6 |
|
| ||
| GO:0034130, Toll-like receptor 1 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 5.33 × 10−6 |
|
| ||
| GO:0030835, Negative regulation of actin filament depolymerization | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 5.58 × 10−6 |
|
| ||
| GO:0015629, Actin cytoskeleton | WAS, CDH1, BRCA1, SPTB, SPTBN1, SPTAN1, CTDP1, STX1A, SPTA1, PAK1, SNCA, ADD1, EPB41, EPB49 | 5.58 × 10−6 |
|
| ||
| GO:0002755, MyD88-dependent toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 7.66 × 10−6 |
|
| ||
| GO:0034142, Toll-like receptor 4 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 1.14 × 10−5 |
|
| ||
| GO:0050679, Positive regulation of epithelial cell proliferation | FGF2, CTNNB1, AGGF1, HIF1A, TNFSF12, ARNT, MYC, JUN, FGF1 | 1.14 × 10−5 |
|
| ||
| MIMAT0000076(hsa-miR-21-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0030834, Regulation of actin filament depolymerization | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 1.27 × 10−5 |
|
| ||
| GO:0030837, Negative regulation of actin filament polymerization | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 2.71 × 10−5 |
|
| ||
| GO:0002224, Toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 2.96 × 10−5 |
|
| ||
| GO:0008629, Induction of apoptosis by intracellular signals | PML, BRCA1, YWHAB, TP53, BID, CDKN1A, RNF7, IFI16 | 3.52 × 10−5 |
|
| ||
| GO:0043067, Regulation of programmed cell death | SPRY2, TP53, ADAMTSL4, ETS1, TDGF1, RAF1, HOXA5, HOXA13, MSX1, MSX2, NKX2-5, CBL, INHBB, COL4A3, ACVR1C, TRAF2 | 1.92 × 10−5 |
| GO:0007173, Epidermal growth factor receptor signaling pathway | SPRY2, SPRY1, GRB2, PTPN11, TDGF1, RAF1, CBL | 9.44 × 10−5 |
|
| ||
| MIMAT0000250(hsa-miR-139-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0035583, Negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta | LTBP1, FBN1, FBN2 | 2.61 × 10−5 |
|
| ||
| MIMAT0000089(hsa-miR-31-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0007187, G-protein signaling, coupled to cyclic nucleotide second messenger | GNA12, GNA13, DRD5, MTNR1A, S1PR3, TSHR, S1PR4 | 8.74 × 10−7 |
|
| ||
| GO:0019935, Cyclic-nucleotidemediated signaling | GNA12, GNA13, DRD5, MTNR1A, S1PR3, TSHR, S1PR4 | 1.60 × 10−6 |
|
| ||
| GO:0007188, G-protein signaling, coupled to cAMP nucleotide second messenger | GNA12, GNA13, DRD5, S1PR3, TSHR, S1PR4 | 6.82 × 10−6 |
|
| ||
| GO:0048011, Nerve growth factor receptor signaling pathway | ARHGEF1, PRKCD, ARHGEF12, PRKACA, PRKCE, MCF2, ARHGEF11 | 6.93 × 10−6 |
|
| ||
| GO:0019933, CAMP-mediated signaling | GNA12, GNA13, DRD5, S1PR3, TSHR, S1PR4 | 1.05 × 10−5 |
|
| ||
| GO:0043067, Regulation of programmed cell death | PTK2B, PRKCD, TGFBR1, ARHGEF12, CTNNB1, PRKCE, TIA1, MCF2, FASTK, ARHGEF11, F2R | 1.25 × 10−5 |
|
| ||
| GO:0003376, Sphingosine-1- phosphate signaling pathway | S1PR3, S1PR2, S1PR4 | 3.22 × 10−5 |
|
| ||
| GO:0007169, Transmembrane receptor protein tyrosine kinase signaling pathway | PTK2B, ARHGEF1, PRKCD, ARHGEF12, PRKACA, PRKCE, MCF2, ARHGEF11 | 5.20 × 10−5 |
|
| ||
| GO:0043068, Positive regulation of programmed cell death | TGFBR1, ARHGEF12, CTNNB1, PRKCE, TIA1, MCF2, FASTK, ARHGEF11 | 7.67 × 10−5 |
|
| ||
| GO:0010942, Positive regulation of cell death | TGFBR1, ARHGEF12, CTNNB1, PRKCE, TIA1, MCF2, FASTK, ARHGEF11 | 8.78 × 10−5 |
|
| ||
| GO:0006917, Induction of apoptosis | TGFBR1, ARHGEF12, PRKCE, TIA1, MCF2, FASTK, ARHGEF11 | 9.32 × 10−5 |
| GO:0012502, Induction of programmed cell death | TGFBR1, ARHGEF12, PRKCE, TIA1, MCF2, FASTK, ARHGEF11 | 9.51 × 10−5 |
|
| ||
| MIMAT0000437(hsa-miR-145-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0030509, BMP signaling pathway | BMP6, ZNF8, ACVR1, SMAD1, SMAD4, RYR2, SMAD5, SMURF2, GDF6 | 1.37 × 10−11 |
|
| ||
| GO:0007178, Transmembrane receptor protein serine/threonine kinase signaling pathway | BMP6, ZNF8, ACVR1, SMAD1, SMAD4, RYR2, SMAD5, SMURF2, GDF6 | 2.56 × 10−8 |
|
| ||
| GO:0090092, Regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | MEN1, TP53, BMP6, HOXA13, ACVR1, SMAD4, SULF1, SMURF2, GDF6 | 8.22 × 10−8 |
|
| ||
| MIMAT0000064(hsa-let-7c) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0043067, Regulation of programmed cell death | RRM2B, ACVR1, TP53, RASA1, TGFBR1, PSMA3, BIRC5, ACTN2, HOXA13, IRS2, FASTK, VAV1, PSMB6, BCL2, CDK1, HDAC1, SOX10, TIA1, AKT1, AURKB | 3.43 × 10−8 |
|
| ||
| GO:0043069, Negative regulation of programmed cell death | RRM2B, ACVR1, TP53, RASA1, TGFBR1, BIRC5, IRS2, BCL2, CDK1, HDAC1, SOX10, AKT1, AURKB | 6.58 × 10−6 |
|
| ||
| GO:0060548, Negative regulation of cell death | RRM2B, ACVR1, TP53, RASA1, TGFBR1, BIRC5, IRS2, BCL2, CDK1, HDAC1, SOX10, AKT1, AURKB | 8.92 × 10−6 |
|
| ||
| GO:0015630, Microtubule cytoskeleton | INCENP, SNTB2, SEPT1, TACC1, BIRC5, RACGAP1, PIN4, CDCA8, CDK1, PHF1, AKT1, AURKB, NINL, CCDC85B | 5.15 × 10−5 |
|
| ||
| GO:0043067, Regulation of programmed cell death | HMGA2, PML, PRNP, FGF2, XRCC4, BRCA1, IGFBP3, HDAC3, CTNNB1, CD5, CDK1, NKX2-5, MEF2C, PRKCI, CASP2, PSMA4, PSMA3, CFDP1, CAV1, FAF1, YWHAB, HIF1A, RELA, TCF7L2, TNFSF12, PSEN2, TP53, TOP2A, TNFRSF4, BID, MYC, JUN, OGT, CDKN1A, RNF7, PPP2R4, HDAC2, HDAC1, SNCA, PTEN, NFKBIA, IFI16, NOL3, TRAF2, HSP90B1 | 1.62 × 10−23 |
|
| ||
| GO:0060548, Negative regulation of cell death | HMGA2, PRNP, FGF2, XRCC4, HDAC3, CTNNB1, CDK1, NKX2-5, MEF2C, PRKCI, CFDP1, HIF1A, RELA, TCF7L2, PSEN2, TP53, TNFRSF4, MYC, JUN, CDKN1A, RNF7, HDAC2, HDAC1, SNCA, PTEN, MGMT, NFKBIA, NOL3, HSP90B1 | 4.53 × 10−17 |
|
| ||
| GO:0008284, Positive regulation of cell proliferation | HMGA2, FGF2, XRCC4, CDC25B, CTNNB1, EGR1, AGGF1, CDK1, NKX2-5, MEF2C, PRKCI, IRS1, HIF1A, RELA, HCLS1, TNFSF12, ARNT, PTPRC, TNFSF4, TNFRSF4, MYC, JUN, FGF1, CDKN1A, HDAC2, HDAC1, NOLC1, PTEN | 1.23 × 10−15 |
|
| ||
| MIMAT0000443(hsa-miR-125a-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0043069, Negative regulation of programmed cell death | HMGA2, PRNP, XRCC4, HDAC3, CTNNB1, CDK1, NKX2-5, MEF2C, PRKCI, CFDP1, HIF1A, RELA, TCF7L2, PSEN2, TP53, TNFRSF4, MYC, JUN, CDKN1A, RNF7, HDAC2, HDAC1, SNCA, PTEN, NFKBIA, NOL3, HSP90B1 | 2.02 × 10−15 |
|
| ||
| GO:0043068, Positive regulation of programmed cell death | HMGA2, PML, BRCA1, IGFBP3, CTNNB1, CD5, MEF2C, PRKCI, CASP2, CAV1, FAF1, YWHAB, TNFSF12, PSEN2, TP53, TOP2A, BID, JUN, OGT, CDKN1A, RNF7, PPP2R4, PTEN, IFI16, TRAF2 | 2.80 × 10−13 |
|
| ||
| GO:0010942, Positive regulation of cell death | HMGA2, PML, BRCA1, IGFBP3, CTNNB1, CD5, MEF2C, PRKCI, CASP2, CAV1, FAF1, YWHAB, TNFSF12, PSEN2, TP53, TOP2A, BID, JUN, OGT, CDKN1A, RNF7, PPP2R4, PTEN, IFI16, TRAF2 | 4.35 × 10−13 |
|
| ||
| GO:0006916, Anti-apoptosis | PRNP, HDAC3, CDK1, NKX2-5, MEF2C, PRKCI, CFDP1, RELA, TCF7L2, PSEN2, RNF7, HDAC1, SNCA, NFKBIA, NOL3, HSP90B1 | 9.04 × 10−11 |
|
| ||
| GO:0008285, Negative regulation of cell proliferation | SERPINF1, SRF, PML, PRNP, FGF2, CSNK2B, IGFBP3, CTNNB1, CAV1, HMGA1, VDR, CDH5, HSF1, COL18A1, TP53, MYC, JUN, CDKN1A, PAK1, PTEN | 1.32 × 10−9 |
|
| ||
| GO:0015630, Microtubule cytoskeleton | STMN1, KIF1C, RANGAP1, CDC25B, BRCA1, HDAC3, CTNNB1, PIN4, HSPH1, RANBP9, CDK1, SPTAN1, YWHAQ, DVL1, FKBP4, YWHAB, CCDC85B, MAPT, PSEN2, TOP2A, SPIB, MYC, OGT, APEX1, PAFAH1B1 | 1.32 × 10−9 |
|
| ||
| GO:0048011, Nerve growth factor receptor signaling pathway | HDAC3, CDK1, MEF2C, PRKCI, CASP2, IRS1, YWHAB, RELA, PSEN2, HDAC2, HDAC1, PTEN, ATF1, NFKBIA | 1.50 × 10−8 |
|
| ||
| GO:0050678, Regulation of epithelial cell proliferation | SERPINF1, PGR, FGF2, CTNNB1, AGGF1, CAV1, HIF1A, TNFSF12, ARNT, MYC, JUN, FGF1, PTEN | 2.66 × 10−8 |
|
| ||
| GO:0007169, Transmembrane receptor protein tyrosine kinase signaling pathway | FGF2, HDAC3, CDK1, MEF2C, PRKCI, CASP2, IRS1, FIBP, PTPN1, YWHAB, RELA, PSEN2, FGF1, HDAC2, HDAC1, PTEN, ATF1, NFKBIA, EIF4EBP1 | 4.37 × 10−8 |
|
| ||
| GO:0006917, Induction of apoptosis | PML, BRCA1, CD5, CASP2, CAV1, YWHAB, TNFSF12, PSEN2, TP53, BID, OGT, CDKN1A, RNF7, PTEN, IFI16, TRAF2 | 1.22 × 10−7 |
|
| ||
| GO:0012502, Induction of programmed cell death | PML, BRCA1, CD5, CASP2, CAV1, YWHAB, TNFSF12, PSEN2, TP53, BID, OGT, CDKN1A, RNF7, PTEN, IFI16, TRAF2 | 1.31 × 10−7 |
|
| ||
| GO:0035666, TRIF-dependent toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 2.01 × 10−6 |
|
| ||
| GO:0034138, Toll-like receptor 3 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 2.27 × 10−6 |
|
| ||
| GO:0051693, Actin filament capping | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 2.97 × 10−6 |
|
| ||
| GO:0002756, MyD88- independent toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 3.20 × 10−6 |
|
| ||
| GO:0015629, Actin cytoskeleton | WAS, CDH1, BRCA1, SPTB, SPTBN1, SPTAN1, CTDP1, STX1A, SPTA1, PAK1, SNCA, ADD1, EPB41, EPB49 | 4.25 × 10−6 |
|
| ||
| GO:0034134, Toll-like receptor 2 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 4.43 × 10−6 |
|
| ||
| GO:0034130, Toll-like receptor 1 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 4.43 × 10−6 |
|
| ||
| GO:0030835, Negative regulation of actin filament depolymerization | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 4.72 × 10−6 |
|
| ||
| GO:0002755, MyD88-dependent toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 6.41 × 10−6 |
|
| ||
| GO:0050679, Positive regulation of epithelial cell proliferation | FGF2, CTNNB1, AGGF1, HIF1A, TNFSF12, ARNT, MYC, JUN, FGF1 | 9.31 × 10−6 |
|
| ||
| GO:0034142, Toll-like receptor 4 signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 9.31 × 10−6 |
|
| ||
| GO:0030834, Regulation of actin filament depolymerization | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 1.09 × 10−5 |
|
| ||
| GO:0030837, Negative regulation of actin filament polymerization | SPTB, SPTBN1, SPTAN1, SPTA1, ADD1, EPB49 | 2.37 × 10−5 |
|
| ||
| GO:0002224, Toll-like receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 2.48 × 10−5 |
|
| ||
| GO:0008629, Induction of apoptosis by intracellular signals | PML, BRCA1, YWHAB, TP53, BID, CDKN1A, RNF7, IFI16 | 2.92 × 10−5 |
|
| ||
| GO:0050851, Antigen receptor-mediated signaling pathway | WAS, MEF2C, RELA, PSEN2, PTPRC, PAK1, PTEN, NFKBIA | 8.55 × 10−5 |
|
| ||
| GO:0002221, Pattern recognition receptor signaling pathway | ATF2, CDK1, MEF2C, FOS, RELA, JUN, ATF1, NFKBIA | 9.15 × 10−5 |
|
| ||
| GO:0001936, Regulation of endothelial cell proliferation | FGF2, AGGF1, CAV1, HIF1A, TNFSF12, ARNT, JUN | 9.47 × 10−5 |
|
| ||
| MIMAT0000077(hsa-miR-22-3p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0035583, Negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta | FBN2, FBN1, LTBP1 | 1.45 × 10−5 |
|
| ||
| MIMAT0000265(hsa-miR-204-5p) | ||
|
| ||
| GO term | Genes | Adj.p-value |
|
| ||
| GO:0035583, Negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta | FBN1, FBN2, LTBP1 | 6.31 × 10−5 |