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. 2013 Jun 7;14(6):12297–12312. doi: 10.3390/ijms140612297

Figure 4.

Figure 4

Reductions in viability of EJ28 cells after siRNA-mediated inhibition of Bcl-xL and survivin, with or without subsequent chemotherapy (CT). EJ28 cells were transfected with a total of 40 nM siRNAs for four hours. Twenty-four hours after transfection start, cells were treated with 2.1 μg/mL cisplatin (CDDP) for 24 h or with 0.9 μg/mL mitomycin C (MMC) for two hours. Cell viability was examined 96 h after transfection. Values shown are relative to the control siRNA “ns-si” (=100%, for all siRNA treatments) or relative to untreated cells (only for CDDP and MMC single treatments) and are averages of a fourfold determination. Error bars represent the 95% confidence interval. An unpaired Student’s t-test was used to compare the differences in cell viability between target-specific siRNA and ns-si treated cells (*p ≤ 0.05) as well as between target-specific siRNA + CT and ns-si + CT treated cells (#p ≤ 0.05).