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. 2013 Jun 17;14(6):12661–12674. doi: 10.3390/ijms140612661

Figure 1.

Figure 1

(A) The conformational superimposition of proteins encoding the Protein tyrosine phosphatase 1B (PTP1B) and protein tyrosine phosphatase (PTP) domain of SHP-2 with novel ligands and (B) the surface map of PTP1B within a 4 Å radius designed around the molecules. The blue surface indicates the catalytic site of the two proteins, while the area colored in red represents site B of PTP1B. Ligands with grey, green and orange colored carbon atoms represent Compounds 13, 15 and 20, respectively.