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Effects of SN on FD-4 flux in Caco-2 cell monolayers (A-B). Control group means 0.1% FD-4 alone, SN group means 0.5% SN + 0.1% FD-4, SN + Ro318220 group means 0.5% SN + 10 μM Ro318220 + 0.1% FD-4. Permeation clearance of FD-4 was calculated at 120min for each groups. * p(SN group vs. control group at 120 min) < 0.05, #p(SN + Ro318220 group vs. control group at 120 min) > 0.05.
