Table 3.
Summary of behavior QTL in DO mice
| Positional Candidates | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Traits | Chr | Peak Marker | LOD | 1.5 LOD CI (Mb) | Interval Width (Mb) | Protein Coding | Pseudo- gene | miRNA | Total | % VAF QTL |
| Time in center slope in the open-field | 4 | backupUNC040363260 | 8.20 | 147.68–149.29 | 1.61 | 25 | 7 | 0 | 32 | 12.81 |
| Immobility in | 2 | backupUNC021331957 | 7.82 | 93.2–100.21 | 7 | 12 | 21 | 2 | 35 | 11.43 |
| open-field | 6 | JAX00145678 | 8.63 | 114.07–115.94 | 1.87 | 12 | 3 | 0 | 15 | 12.53 |
| 19* | UNC190040392 | 6.80 | 34.53–36.27 | 1.74 | 14 | 5 | 2 | 21 | ||
| % Time spent in light side of light–dark box* | 8 | JAX00679421 | 7.14 | 107.54–110.44 | 2.89 | 82 | 11 | 3 | 96 | 10.83 |
| Time in light slope in the light–dark box | 11 | UNC110549757 | 7.40 | 95.01–96.55 | 1.53 | 33 | 5 | 3 | 41 | 11.1 |
| Climbing frequency during tail-suspension test | 6 | UNC060396166 | 8.69 | 97.77–98.9 | 1.12 | 3 | 2 | 0 | 5 | 13.74 |
| Distance traveled (ratio) in bottom area of visual-cliff* | 14 | UNC140101805 | 6.95 | 21.55–23.18 | 1.63 | 13 | 1 | 0 | 14 | 10.89 |
*
Suggestive QTL P < 0.10.