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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Eur Urol. 2012 Sep 28;63(2):244–251. doi: 10.1016/j.eururo.2012.09.054

Fig. 1.

Fig. 1

Hypoxia-inducible factor (HIF) accumulation resulting from von Hippel-Lindau (VHL) loss regulates several metabolic processes. HIF promotes the expression of many genes that encode glycolytic enzymes. HIF also prevents entry and metabolism through the tricarboxylic acid (TCA) cycle via several mechanisms including (1) promoting pyruvate conversion to lactate, (2) blocking pyruvate conversion to acetyl-coenzyme A, and (3) lowering the expression of enzymes involved in oxidative phosphorylation.