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. Author manuscript; available in PMC: 2013 Jul 12.
Published in final edited form as: Cancer Discov. 2013 Mar;3(3):255–257. doi: 10.1158/2159-8290.CD-13-0018

Figure 1.

Figure 1

Inhibition of BRD4 complex acetyl-lysine recognition by JQ1. A, BRD4 binds to the MYCN promoter at acetyl-lysine residues, recruiting additional proteins (such as the histone methyltransferase NSD3) that mediate chromatin density and allow for active MYCN transcription. MYCN target genes subsequently increase cellular proliferation by fostering cell-cycle progression as well as inhibiting apoptosis and blocking neuronal differentiation. B, JQ1 displaces BRD4 from the MYCN promoter, thus inhibiting MYCN transcription and leading to cell-cycle arrest, increased apoptosis, and increased neuritogenesis required for terminal differentiation.