(A, B) A 90-year-old woman with history of primary lung carcinoma status postradiation, with recurrence of the tumor. High central metabolic activity is noted on positron emission tomography (PET). (C) Three probes were placed in the mass. Simultaneous cryoablation was performed with the ice balls (arrow), merging to create a large ablation zone. (D) At 2 months postablation, PET scan demonstrated a central metabolic area with thin rim of metabolic activity not exceeding that of the mediastinum. Despite a presumed favorable response, PET should be repeated in 6 months to confirm absence of residual tumor.