Table 2. Recent outcomes in lung cancer patients with central tumors.
| Study | Outcome | Total dose | Fractional dose | Toxicity |
|---|---|---|---|---|
| Haasbeek et al28 (n = 63) |
3-y LC: 92.6%; 3-y OAS: 64.3% | 60 Gy | 7.5 Gy × 8f | Chest wall grade III (n = 2), dyspnea (n = 2), no grade IV/V |
| Janssen et al29 (n = 65; 29 central tumors) |
Six local recurrences: 1-y LC: 93%; OAS: 79% | 40 Gy (3 patients) 48 Gy (26 patients) |
8 Gy × 5f 8 Gy × 6f |
Grade 1 and 2 pneumonitis 21.5% |
| Peulen et al30 reirradiation (n = 29; 32 lesions) |
LC at 5 mo was 52%; 2-y survival: 43% | Grade 3 and4 toxicity scored 14 times in 8 patients |
Abbreviations: LC, local control; OAS, overall survival; f, fraction.