Table 1. Main characteristics and CpG methylation levels in the IL2RA promoter of T1D patients and age-matched non-diabetic controls.
T1D Patients | Controls | pvalue | |
N | 252 | 286 | |
Sex (M/F) | 132/120 | 130/156 | |
Current age (yrs) | 11.45±4.13 | 11.08±3.09 | 0.19 |
BMI (kg/m2) | 18.67±3.07 | 21.63±9.51 | 0.86 |
Age at clinical onset (yrs) | 6.22±3 | – | – |
Diabetes Duration | 5.24±3.71 | – | – |
Hba1c | 8.09±1.32 | – | – |
CpG-241 | 9.74±1.91 | 9.94±2.72 | 0.71 |
CpG-272 | 1.7±1.79 | 1.92±2.02 | 0.38 |
CpG-356 | 6.24±1.27 | 5.94±2.11 | 0.017 |
CpG-373 | 40.38±4.64 | 38.34±5.46 | 1.4.10−4 |
CpG-456 | 91.43±2.77 | 89.5±5.3 | 1.79.10−6 |
CpG-459 | 82.32±4.5 | 82.34±4.57 | 0.82 |
Results are expressed as mean ± sd.