Figure 7. Conserved subnetwork regions in the 3-way alignment of D. melanogaster, H. sapiens, and S. cerevisiae using the proposed method.

(A) Transcription factor. (B) Replication factor C. (C) RNA polymerase. (D) DNA replication. (Aligned nodes are placed in the same row of alignment and connected with yellow dashed lines. In each network, the interaction in the IsoBase dataset is shown in solid lines. For D. melanogaster some edges which are missed in IsoBase but are present in STRING protein interaction database [52] is shown in dotted gray lines).