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Schematic of the effect of whisker stimulation on outcome depending on timing of administration. Complete protection is observed in all subjects when stimulation is delivered within the first hour following permanent middle cerebral artery occlusion (pMCAO), but only in about 70% of subjects when delivered at 2 hours post-pMCAO. By 3 hours post-pMCAO, whisker stimulation not only ceases to be beneficial, but actually exacerbates impending stroke damage.
