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. 2012 Feb 8;32(6):2121–2128. doi: 10.1523/JNEUROSCI.4752-11.2012

Figure 1.

Figure 1.

Partial repopulation of the retina with rod photoreceptors in bP23H animals. A, A′, Wild-type retina. B, B′, bP23H transgenic retina reared in cyclic light since fertilization. C, C′, P23H transgenic retina reared in complete darkness for 3 weeks after initial (21 d) exposure to light. Retinal cryosections were stained with WGA (green) and Hoechst (blue). IS, Inner segment; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bars: top, 100 μm; bottom, 20 μm. D, Relative thickness of tadpole retinas under normal cyclic light or dark-recovered rearing conditions as measured from histological sections (n > 6, mean ± SD). The asterisk indicates that the relative thickness of the dark-recovered bP23H retina is significantly thicker than the cyclic light-reared bP23H retina (Student's t test, p < 0.0002). WT, Wild-type.