Figure 4.

Apoptosis in bP23H retinas reared in cyclic light is comparable with WT retinas in cyclic light. Comparison of wild-type retina (left) versus bP23H retina (right) after 9 weeks in cyclic light. The arrowheads point to TUNEL-positive (red) ONL cells. Insets show enlargements of respective boxed areas. The number of TUNEL-positive cells in the ONL were counted over a 9 week period. The highest number of TUNEL-positive ONL cells per section per retina at week 9 is shown (n > 3, mean ± SEM). WGA, Green; Hoechst nuclear stain, blue. Scale bars: 100 μm; inset, 10 μm.