Skip to main content
. Author manuscript; available in PMC: 2014 Jul 15.
Published in final edited form as: J Immunol. 2013 Jun 19;191(2):572–582. doi: 10.4049/jimmunol.1300299

Figure 5.

Figure 5

CD8+ marginal zone DCs play a critical role in iNKT cell cytokine production following pneumococcal infection. (A) The frequency of IFNγ-producing iNKT cells or (B) serum IL-12p40 levels in S. pneumoniae infected animals under conditions shown in Fig. 4A. (C) The frequency of IFNγ-producing iNKT cells or (D) serum IL-12p40 levels in naïve or S. pneumonaie infected WT or batf3−/− animals. (E) The frequency of IFNγ producing iNKT cells following PBS, αGalCer, or IL-12/IL-18 administration 24 hours after clodronate-mediated phagocyte depletion. Data are representative of three (E) and two (A–D) experiments. Error bars represent standard deviation of at least three mice per group. * p<0.02; ** p<0.001; *** p<0.0001;ns, not significant.