Table 3.

Multiple Linear Regression Analyses Predicting LOH Frequency from Telomere Length or Attrition by Chromosome Arm and Cell Type

% of LOH by Chromosome arm	TL in Cancer cells			TL in CAFs			TL in Lymphocytes			Telomere attrition in cancer cells
	Slope	SE	P	Slope	SE	P	Slope	SE	P	Slope	SE	P
1p	−2.9	6.6	0.668	11.9	6.8	0.089	5.5	5.5	0.328	11.0	5.7	0.069
1q	−1.0	5.8	0.864	1.1	6.2	0.864	3.4	4.8	0.487	1.6	5.2	0.767
3q	3.3	5.4	0.546	4.4	5.8	0.453	5.5	4.5	0.230	4.3	4.9	0.931
4p	15.7	9.6	0.112	26.0	9.7	0.011	13.2	8.1	0.112	5.6	8.9	0.531
4q	14.2	9.4	0.138	31.8	8.8	0.001	20.9	7.3	0.007	10.8	8.5	0.209
5p	−1.3	5.2	0.807	11.5	5.2	0.036	3.6	4.3	0.412	9.0	4.4	0.048
5q	−2.9	8.7	0.738	23.1	8.4	0.010	11.8	7.0	0.101	18.5	7.1	0.014
6q	−4.1	7.0	0.556	15.4	7.0	0.035	7.6	5.7	0.195	14.1	5.8	0.020
10q	5.0	7.8	0.531	18.2	7.8	0.027	16.8	6.0	0.008	8.7	6.9	0.214
12p	10.6	5.6	0.066	14.3	5.8	0.019	−1.1	5.0	0.831	1.6	5.3	0.757
12q	11.4	4.4	0.014	19.2	4.0	<0.001	9.8	3.7	0.012	4.3	4.2	0.316
13q	7.7	9.6	0.429	27.1	9.3	0.006	10.2	7.9	0.208	12.8	8.4	0.134
15q	3.7	8.6	0.674	28.4	7.9	0.001	16.8	6.7	0.016	16.9	7.2	0.024
16p	−4.9	5.4	0.370	14.4	5.4	0.011	10.0	4.3	0.026	14.0	4.3	0.003
16q	−2.2	6.1	0.723	15.9	6.0	0.011	8.9	4.9	0.080	13.0	5.0	0.015

LOH = loss of heterozygosity; TL = telomere length; CAFs = carcinoma-associated fibroblasts

Adjusted for age, gender, smoking status, tumor grade, family history of UGI cancer

All the values for slope and standard error (SE) are × 10⁻⁴.